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'Young' oral fibroblasts are geno/phenotypically distinct

Enoch, Stuart, Peake, Matthew Arnold, Wall, Ivan Bernard, Davies, Lindsay Catrina, Farrier, Jerry N., Giles, Peter James, Kipling, David Glyn, Price, Patricia Elaine, Moseley, Ryan, Thomas, David William and Stephens, Philip 2010. 'Young' oral fibroblasts are geno/phenotypically distinct. Journal of Dental Research 89 (12) , pp. 1407-1413. 10.1177/0022034510377796

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Wound healing within the oral mucosa results in minimal scar formation compared with wounds within the skin. We have recently demonstrated distinct differences in the aging profiles of cells (oral mucosal and patient-matched skin fibroblasts) isolated from these tissues. We hypothesized that the increased replicative potential of oral mucosal fibroblasts may confer upon them preferential wound-healing capacities. Passage-matched early cultures of oral mucosal fibroblasts and skin fibroblasts demonstrated distinct gene expression profiles, with several genes linked to wound healing/tissue repair. This was related to an increased ability of the 'replicatively younger' oral mucosal fibroblasts to repopulate a wound space and reorganize their surrounding extracellular matrix environment, key activities during the wound-healing process. We conclude that oral mucosal fibroblasts exhibit a preferential healing response in vivo, due to their 'replicatively younger' phenotype when compared with that of patient-matched skin fibroblasts.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RK Dentistry
Uncontrolled Keywords: wound healing; fibroblast; aging; genotype; phenotype
Publisher: SAGE Publications
ISSN: 0022-0345
Last Modified: 04 Apr 2019 23:23

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