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Synthetic diamond films as a platform material for label-free protein sensors

Bijnens, Nathalie, Vermeeren, Veronique, Daenen, Michaël, Grieten, Lars, Haenen, Ken, Wenmackers, Sylvia, Williams, Oliver Aneurin, Ameloot, Marcel, vandeVen, Martin, Michiels, Luc and Wagner, Patrick 2009. Synthetic diamond films as a platform material for label-free protein sensors. Physica Status Solidi a Applications and Materials Science 206 (3) , pp. 520-526. 10.1002/pssa.200880485

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In the framework of developing a fast and label-free immunosensor for C-reactive protein (CRP) detection, H-terminated nanocrystalline diamond (NCD) was functionalised with anti-CRP antibodies that were physically adsorbed to the surface. Impedance spectroscopy was used to electronically detect real-time CRP recognition. Different impedance behaviours were observed after CRP addition as compared to after FITC-labelled ssDNA addition at low (100 Hz) as well as at high frequencies (1 MHz). Physical interpretations of the observed impedance changes were obtained by fitting the data to an equivalent electrical circuit. Concentrations of 1 μM CRP were recognised with a reaction time of 30 minutes. (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

Item Type: Article
Date Type: Publication
Status: Published
Schools: Physics and Astronomy
Subjects: Q Science > QC Physics
Publisher: Wiley
ISSN: 1862-6300
Last Modified: 04 Jun 2017 03:12

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