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Multi-photon microscopy based on resonant four-wave mixing of colloidal quantum dots

Masia, Francesco, Langbein, Wolfgang Werner and Borri, Paola 2009. Multi-photon microscopy based on resonant four-wave mixing of colloidal quantum dots. Presented at: Colloidal quantum dots for biomedical applications IV, San Jose, CA, USA, 24 January 2009. Published in: Osinski, M., Jovin, T. M. and Yamamoto, K. eds. Colloidal Quantum Dots for Biomedical Applications IV: Saturday 24 January 2009, San Jose, CA, USA. Proceedings of SPIE , vol. 7189-3. Bellingham, WA: SPIE - International Society for Optical Engineering, 71890Z. 10.1117/12.807968

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We demonstrate a novel multi-photon imaging modality based on the detection of four-wave mixing (FWM) from colloidal nanoparticles. Four-wave mixing is a third-order signal which can be excited and detected in resonance with the ground-state excitonic transition of CdSe/ZnS quantum dots. The coherent FWM signal is detected interferometrically to reject incoherent backgrounds for improved image contrast compared to fluorescence methods. We measure transversal and axial resolutions of 140nm and 590nm respectively, significantly beating the one-photon diffraction limit. We also demonstrate optical imaging of quantum-dot-labeled Golgi structures of HepG2 cells.

Item Type: Conference or Workshop Item (Paper)
Date Type: Publication
Status: Published
Schools: Biosciences
Physics and Astronomy
Subjects: T Technology > T Technology (General)
T Technology > TA Engineering (General). Civil engineering (General)
T Technology > TK Electrical engineering. Electronics Nuclear engineering
Uncontrolled Keywords: Four wave mixing ; Multiphoton microscopy ; Quantum dots ; Photons ; Diffraction ; Nanoparticles ; Optical imaging ; Luminescence
Publisher: SPIE - International Society for Optical Engineering
ISBN: 9780819474353
ISSN: 1605-7422
Last Modified: 06 Aug 2020 15:32

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