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Design of photocontrolled RNA-binding peptidomimetics

Mart, Robert J., Wysoczanski, Piotr, Kneissl, Sabine, Ricci, Antonio, Brancale, Andrea and Allemann, Rudolf Konrad 2012. Design of photocontrolled RNA-binding peptidomimetics. ChemBioChem 13 (4) , pp. 515-519. 10.1002/cbic.201100800

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The first examples of photocontrolled RNA binding peptides are described. The large number of positively charged sides chains in the Rev response element (RRE) of an HIV type I targeting α-helix imposes constraints on the choice of azobenzene-derived crosslinker.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Cardiff Catalysis Institute (CCI)
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords: azo compounds; peptides; photochromism; protein modifications; RNA recognition
Publisher: Wiley
ISSN: 1439-4227
Funders: EPSRC
Last Modified: 24 Nov 2020 02:20

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