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Individual differences in the functional neuroanatomy of inhibitory control

Garavan, Hugh, Hester, Robert, Murphy, Kevin, Fassbender, Catherine and Kelly, Clare 2006. Individual differences in the functional neuroanatomy of inhibitory control. Brain Research 1105 (1) , pp. 130-142. 10.1016/j.brainres.2006.03.029

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We combined the data of five event-related fMRI studies of response inhibition. The re-analysis (n = 71) revealed response inhibition to be accomplished by a largely right hemisphere network of prefrontal, parietal, subcortical and midline regions, with converging evidence pointing to the particular importance of the right frontal operculum. Functional differences were observed between the sexes with greater activity in females in many of these cortical regions. Despite the relatively narrow age range (18–46), cortical activity, on the whole, tended to increase with age, echoing a pattern of functional recruitment often observed in the elderly. More absentminded subjects showed greater activity in fronto-parietal areas, while speed of Go trial responses produced a varied pattern of activation differences in more posterior and subcortical areas. Although response inhibition produces robust activation in a discrete network of brain regions, these results reveal that individual differences impact on the relative contribution made by the nodes of this network.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Physics and Astronomy
Cardiff University Brain Research Imaging Centre (CUBRIC)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Inhibition; Individual Differences; Cognitive Control
Publisher: Elsevier
ISSN: 0006-8993
Last Modified: 08 May 2019 14:04

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