The association between conduct problems and the initiation and progression of marijuana use during adolescence: A genetic analysis across time

Shelton, Katherine Helen ORCID: https://orcid.org/0000-0002-1311-5291, Lifford, Kate ORCID: https://orcid.org/0000-0002-9782-2080, Fowler, Tom, Rice, Frances ORCID: https://orcid.org/0000-0002-9484-1729, Harold, Gordon Thomas, Thapar, Anita ORCID: https://orcid.org/0000-0002-3689-737X and van den Bree, Marianne Bernadette ORCID: https://orcid.org/0000-0002-4426-3254 2007. The association between conduct problems and the initiation and progression of marijuana use during adolescence: A genetic analysis across time. Behavior Genetics 37 (2) , pp. 314-325. 10.1007/s10519-006-9124-1

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Abstract

The present study used a prospective, longitudinal design to investigate genetic and environmental influences on the association between earlier conduct problems and the initiation and progression of marijuana use during adolescence. Parent- and teacher-reported conduct problems assessed at Time 1 (1996) and self-reported marijuana use assessed at Time 2 (2004) were available for 1088 adolescent twin pairs participating in the Cardiff Study of All Wales and North West of England Twins (CaStANET). Using a novel approach to the modeling of initiation and progression dimensions in substance use, findings suggested that the initiation of marijuana use in adolescence was influenced by genetic, common and unique environmental factors. The progression (or frequency) of marijuana use was influenced by genetic and unique environmental factors. Findings for conduct problems indicated that while the presence or absence of conduct problems was largely heritable, the relative severity of conduct problems appeared to be more strongly environmentally influenced. Multivariate model fitting indicated that conduct problems in childhood and early adolescence made a small but significant contribution to the risk for marijuana use 8 years later.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI) Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology Q Science > QH Natural history > QH426 Genetics
Uncontrolled Keywords:	Conduct problems,� Marijuana use, Adolescence , Initiation, Longitudinal,� Genetic, Environmental
Publisher:	Springer Verlag
ISSN:	0001-8244
Last Modified:	06 May 2023 01:40
URI:	https://orca.cardiff.ac.uk/id/eprint/3442

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