Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Emergence and global spread of epidemic healthcare-associated Clostridium difficile [Letter]

He, Miao, Miyajima, Fabio, Roberts, Paul, Ellison, Louise, Pickard, Derek J., Martin, Melissa J., Connor, Thomas Richard ORCID: https://orcid.org/0000-0003-2394-6504, Harris, Simon R., Fairley, Derek, Bamford, Kathleen B., D'Arc, Stephanie, Brazier, J. S., Brown, Derek, Coia, John E., Douce, Gill, Gerding, Dale, Kim, Hee Jung, Koh, Tse Hsien, Kato, Haru, Senoh, Mitsutoshi, Louie, Tom, Michell, Stephen, Butt, Emma, Peacock, Sharon J., Brown, Nick M., Riley, Tom, Songer, Glen, Wilcox, Mark, Pirmohamed, Munir, Kuijper, Ed, Hawkey, Peter, Wren, Brendan W., Dougan, Gordon, Parkhill, Julian and Lawley, Trevor D. 2012. Emergence and global spread of epidemic healthcare-associated Clostridium difficile [Letter]. Nature Genetics 45 (1) , pp. 109-113. 10.1038/ng.2478

Full text not available from this repository.

Abstract

Epidemic C. difficile (027/BI/NAP1) has rapidly emerged in the past decade as the leading cause of antibiotic-associated diarrhea worldwide. However, the key events in evolutionary history leading to its emergence and the subsequent patterns of global spread remain unknown. Here, we define the global population structure of C. difficile 027/BI/NAP1 using whole-genome sequencing and phylogenetic analysis. We show that two distinct epidemic lineages, FQR1 and FQR2, not one as previously thought, emerged in North America within a relatively short period after acquiring the same fluoroquinolone resistance–conferring mutation and a highly related conjugative transposon. The two epidemic lineages showed distinct patterns of global spread, and the FQR2 lineage spread more widely, leading to healthcare-associated outbreaks in the UK, continental Europe and Australia. Our analysis identifies key genetic changes linked to the rapid transcontinental dissemination of epidemic C. difficile 027/BI/NAP1 and highlights the routes by which it spreads through the global healthcare system.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology > QR180 Immunology
Publisher: Nature Publishing Group
ISSN: 1061-4036
Last Modified: 24 Oct 2022 10:43
URI: https://orca.cardiff.ac.uk/id/eprint/45652

Citation Data

Cited 513 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item