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Pharmacokinetics of ciprofloxacin in the elderly

Bayer, Antony James, Gajewska, A., Stephens, M., Stark, J. M. and Pathy, J. 1987. Pharmacokinetics of ciprofloxacin in the elderly. Respiration 51 (4) , pp. 292-295.

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The pharmacokinetics of ciprofloxacin, administered orally as a 250-mg tablet were compared in 10 young (age 20-30 years) and 10 elderly (age 60-73 years) healthy volunteers. The time to peak serum concentrations was about 80 min in both age groups, although the maximum concentration attained was significantly greater in the old (1.7 mg/l) than the young (1.2 mg/l). Area under the plasma concentration-time curve, corrected for body weight, was on average 48% greater in the elderly, but the mean terminal elimination half-life was not significantly different, averaging 4.3 h in the old and 3.7 h in the young. Overall 24-hour urinary recovery in both age groups was comparable. The differences may be explained by a reduced volume of distribution of ciprofloxacin in old age and do not suggest a general need for significant dose alteration in the elderly.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Publisher: Karger
ISSN: 0025-7931
Last Modified: 04 Jun 2017 05:14

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