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RETINOBLASTOMA-RELATED protein stimulates cell differentiation in the Arabidopsis root meristem by interacting with cytokinin signaling

Perilli, Serena, Perez-Perez, Jose Manuel, Di Mambro, Riccardo, Peris, Cristina Llavata, Diaz-Trivino, Sara, Del Bianco, Marta, Pierdonati, Emanuela, Moubayidin, Laila, Cruz-Ramirez, Alfredo, Costantino, Paolo, Scheres, Ben and Sabatini, Sabrina 2013. RETINOBLASTOMA-RELATED protein stimulates cell differentiation in the Arabidopsis root meristem by interacting with cytokinin signaling. The Plant Cell 25 (11) , pp. 4469-4478. 10.1105/tpc.113.116632

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Abstract

Maintenance of mitotic cell clusters such as meristematic cells depends on their capacity to maintain the balance between cell division and cell differentiation necessary to control organ growth. In the Arabidopsis thaliana root meristem, the antagonistic interaction of two hormones, auxin and cytokinin, regulates this balance by positioning the transition zone, where mitotically active cells lose their capacity to divide and initiate their differentiation programs. In animals, a major regulator of both cell division and cell differentiation is the tumor suppressor protein RETINOBLASTOMA. Here, we show that similarly to its homolog in animal systems, the plant RETINOBLASTOMA-RELATED (RBR) protein regulates the differentiation of meristematic cells at the transition zone by allowing mRNA accumulation of AUXIN RESPONSE FACTOR19 (ARF19), a transcription factor involved in cell differentiation. We show that both RBR and the cytokinin-dependent transcription factor ARABIDOPSIS RESPONSE REGULATOR12 are required to activate the transcription of ARF19, which is involved in promoting cell differentiation and thus root growth.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QK Botany
Publisher: American Society of Plant Biologists
ISSN: 1040-4651
Last Modified: 16 Jan 2019 21:09
URI: http://orca.cf.ac.uk/id/eprint/57676

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