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CLASP-mediated cortical microtubule organization guides PIN polarization axis [Letter]

Kakar, Klementina, Zhang, Hongtao, Scheres, Ben and Dhonukshe, Pankaj 2013. CLASP-mediated cortical microtubule organization guides PIN polarization axis [Letter]. Nature 495 (7442) , pp. 529-533. 10.1038/nature11980

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Recent evidence indicates a correlation between orientation of the plant cortical microtubule cytoskeleton and localization of polar cargoes1. However, the molecules and mechanisms that create this correlation have remained unknown. Here we show that, in Arabidopsis thaliana, the microtubule orientation regulators CLASP2, 3 and MAP65 (refs 3, 4) control the abundance of polarity regulator PINOID kinase5, 6 at the plasma membrane. By localized upregulation of clathrin-dependent endocytosis7 at cortical microtubule- and clathrin-rich domains orthogonal to the axis of polarity, PINOID accelerates the removal of auxin transporter PIN proteins8, 9, 10 from those sites. This mechanism links directional microtubule organization to the polar localization of auxin transporter PIN proteins, and clarifies how microtubule-enriched cell sides are kept distinct from polar delivery domains. Our results identify the molecular machinery that connects microtubule organization to the regulation of the axis of PIN polarization.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QK Botany
Publisher: Nature Publishing
ISSN: 0028-0836
Last Modified: 16 Jan 2019 21:10

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