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A PHABULOSA/cytokinin feedback loop controls root growth in Arabidopsis

Dello Ioio, Raffaele, Galinha, Carla, Fletcher, Alexander G., Grigg, Stephen P., Molnar, Attila, Willemsen, Viola, Scheres, Ben, Sabatini, Sabrina, Baulcombe, David, Maini, Philip K. and Tsiantis, Miltos 2012. A PHABULOSA/cytokinin feedback loop controls root growth in Arabidopsis. Current Biology 22 (18) , pp. 1699-1704. 10.1016/j.cub.2012.07.005

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Abstract

The hormone cytokinin (CK) controls root length in Arabidopsis thaliana by defining where dividing cells, derived from stem cells of the root meristem, start to differentiate [ 1, 2, 3, 4, 5 and 6]. However, the regulatory inputs directing CK to promote differentiation remain poorly understood. Here, we show that the HD-ZIPIII transcription factor PHABULOSA (PHB) directly activates the CK biosynthesis gene ISOPENTENYL TRANSFERASE 7 (IPT7), thus promoting cell differentiation and regulating root length. We further demonstrate that CK feeds back to repress both PHB and microRNA165, a negative regulator of PHB. These interactions comprise an incoherent regulatory loop in which CK represses both its activator and a repressor of its activator. We propose that this regulatory circuit determines the balance of cell division and differentiation during root development and may provide robustness against CK fluctuations.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH301 Biology
Publisher: Elsevier
ISSN: 0960-9822
Last Modified: 16 Jan 2019 21:10
URI: http://orca.cf.ac.uk/id/eprint/57684

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