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A SCARECROW-RETINOBLASTOMA protein network controls protective quiescence in the Arabidopsis root stem cell organizer

Cruz-Ramírez, Alfredo, Díaz-Triviño, Sara, Wachsman, Guy, Du, Yujuan, Arteága-Vázquez, Mario, Zhang, Hongtao, Benjamins, Rene, Blilou, Ikram, Neef, Anne B., Chandler, Vicki and Scheres, Ben 2013. A SCARECROW-RETINOBLASTOMA protein network controls protective quiescence in the Arabidopsis root stem cell organizer. PLoS Biology 11 (11) , e1001724. 10.1371/journal.pbio.1001724

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Abstract

Quiescent long-term somatic stem cells reside in plant and animal stem cell niches. Within the Arabidopsis root stem cell population, the Quiescent Centre (QC), which contains slowly dividing cells, maintains surrounding short-term stem cells and may act as a long-term reservoir for stem cells. The RETINOBLASTOMA-RELATED (RBR) protein cell-autonomously reinforces mitotic quiescence in the QC. RBR interacts with the stem cell transcription factor SCARECROW (SCR) through an LxCxE motif. Disruption of this interaction by point mutation in SCR or RBR promotes asymmetric divisions in the QC that renew short-term stem cells. Analysis of the in vivo role of quiescence in the root stem cell niche reveals that slow cycling within the QC is not needed for structural integrity of the niche but allows the growing root to cope with DNA damage.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QK Botany
Additional Information: Full text PDF uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/1544-9173/ (accessed 18/08/2014).
Publisher: Public Library of Science
ISSN: 1544-9173
Date of First Compliant Deposit: 30 March 2016
Last Modified: 16 Jan 2019 21:11
URI: http://orca.cf.ac.uk/id/eprint/57715

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