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Metabolic footprinting and systems biology: the medium is the message

Kell, Douglas B., Brown, Marie, Davey, Hazel M., Dunn, Warwick B., Spasic, Irena and Oliver, Stephen G. 2005. Metabolic footprinting and systems biology: the medium is the message. Nature Reviews. Microbiology 3 (7) , pp. 557-565. 10.1038/nrmicro1177

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One element of classical systems analysis treats a system as a black or grey box, the inner structure and behaviour of which can be analysed and modelled by varying an internal or external condition, probing it from outside and studying the effect of the variation on the external observables. The result is an understanding of the inner make-up and workings of the system. The equivalent of this in biology is to observe what a cell or system excretes under controlled conditions - the 'metabolic footprint' or exometabolome - as this is readily and accurately measurable. Here, we review the principles, experimental approaches and scientific outcomes that have been obtained with this useful and convenient strategy.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Computer Science & Informatics
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Q Science > QH Natural history > QH301 Biology
Uncontrolled Keywords: spasic; metabolome; metabolites;
Publisher: Nature Publishing Group
ISSN: 1740-1526
Last Modified: 04 Jun 2017 01:56

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