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Noninvasive methods for the investigation of organisms at low oxygen levels

Lloyd, David 2002. Noninvasive methods for the investigation of organisms at low oxygen levels. Advances in Applied Microbiology 51 , pp. 155-174. 10.1016/S0065-2164(02)51005-4

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Oxygen (O2) produces major effects at almost infinitesimally low concentrations geared either to its disposal or utilization. It is not widely recognized that the air we breathe (20.9% O2; 21.2 kPa O2; 158 mm Hg; equivalent to 278 μMO2 at 37°C) represents excess of O2, even for the most highly aerobic life processes. When studied in vitro, O2-reactive systems have highly avid binding characteristics and become saturated at much lower partial pressures than the ambient air. Techniques for low O2 studies include oxygen measurements, open versus closed systems, and gas mixing. Awareness of this hierarchy of oxygenation states in the circulatory system as well as in mammalian organs, tissues, and cells that provide fundamental insights. Direct interfacing to “biological reactors” can give continuous information on metabolic states. This technology can thereby provide opportunities for immediate corrective action, and for optimization of metabolite production.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Academic Press
ISSN: 0065-2164
Last Modified: 04 Jun 2017 06:36

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