Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Obesity-associated melanocortin-4 receptor mutations are associated with changes in the brain response to food cues

van der Klaauw, Agatha A., Von Dem Hagen, Elisabeth, Keogh, Julia M., Henning, Elana, O'Rahilly, Stephen, Lawrence, Andrew David, Calder, Andrew J. and Farooqi, I. Sadaf 2014. Obesity-associated melanocortin-4 receptor mutations are associated with changes in the brain response to food cues. Journal of Clinical Endocrinology & Metabolism 99 (10) , E2101. 10.1210/jc.2014-1651

PDF - Published Version
Available under License Creative Commons Attribution.

Download (524kB) | Preview


Context: Mutations in the melanocortin-4 receptor (MC4R) represent the commonest genetic form of obesity and are associated with hyperphagia. Objective: The aim of this study was to investigate whether melanocortin signaling modulates anticipatory food reward by studying the brain activation response to food cues in individuals with MC4R mutations. Design/Setting/Participants/Main Outcome Measure: We used functional magnetic resonance imaging to measure blood oxygen level-dependent responses to images of highly palatable, appetizing foods, bland foods, and non-food objects in eight obese individuals with MC4R mutations, 10 equally obese controls, and eight lean controls with normal MC4R genotypes. Based on previous evidence, we performed a region-of-interest analysis centered on the caudate/putamen (dorsal striatum) and ventral striatum. Results: Compared to non-foods, appetizing foods were associated with activation in the dorsal and ventral striatum in lean controls and in MC4R-deficient individuals. Surprisingly, we observed reduced activation of the dorsal and ventral striatum in obese controls relative to MC4R-deficient patients and lean controls. There were no group differences for the contrast of disgusting foods with bland foods or non-foods, suggesting that the effects observed in response to appetizing foods were not related to arousal. Conclusion: We identified differences in the striatal response to food cues between two groups of obese individuals, those with and those without MC4R mutations. These findings are consistent with a role for central melanocortinergic circuits in the neural response to visual food cues.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: The Endocrine Society
ISSN: 0021-972X
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 8 July 2014
Last Modified: 16 Sep 2019 09:24

Citation Data

Cited 13 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics