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Objective monitoring of nasal patency and nasal physiology in rhinitis

Nathan, R., Eccles, Ronald, Howarth, P., Steinsvag, S. and Togias, A. 2005. Objective monitoring of nasal patency and nasal physiology in rhinitis. Journal of Allergy and Clinical Immunology 115 (3) , S442. 10.1016/j.jaci.2004.12.015

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Nasal obstruction can be monitored objectively by measurement of nasal airflow, as evaluated by nasal peak flow, or as airways resistance/conductance as evaluated by rhinomanometry. Peak flow can be measured during inspiration or expiration. Of these measurements, nasal inspiratory peak flow is the best validated technique for home monitoring in clinical trials. The equipment is portable, relatively inexpensive, and simple to use. One disadvantage, however, is that nasal inspiratory peak flow is influenced by lower airway as well as upper airway function. Rhinomanometry is a more sensitive technique that is specific for nasal measurements. The equipment, however, requires an operator, is more expensive, and is not portable. Thus, it is applicable only for clinic visit measures in clinical trials. Measurements require patient cooperation and coordination, and not all can achieve repeatable results. Thus, this objective measure is best suited to laboratory challenge studies involving smaller numbers of selected volunteers.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: R Medicine > RF Otorhinolaryngology
Publisher: Elsevier
ISSN: 0091-6749
Last Modified: 04 Jun 2017 08:02

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