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Association between a PS-1 intronic polymorphism and late onset Alzheimer's disease

Kehoe, P., Williams, Julie, Holmans, Peter Alan, Liddell, M., Lovestone, S., Holmes, C., Powell, J., Neal, J., Wilcock, G. and Owen, Michael John 1996. Association between a PS-1 intronic polymorphism and late onset Alzheimer's disease. NeuroReport 7 (13) , pp. 2155-2158. 10.1097/00001756-199609020-00019

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Previous work suggests an association between allele 1 and the 1-1 genotype of an intronic polymorphism in the presenilin-1 (PS-1) gene and late onset Alzheimer's disease. We found an excess of the 1-1 genotype in our late onset clinical sample (p = 0.006, one-tailed) but not in our postmortem confirmed sample, which instead exhibited an excess of allele 1 (p = 0.02, one-tailed). No interaction between PS-1 and ApoE genotype was detected and the findings remained significant when the effects of ApoE were taken into account (p = 0.03, one-tailed). These results suggest that the PS-1 polymorphism, or a locus in linkage disequilibrium with it, acts as a risk factor for late onset AD.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Lippincott, Williams & Wilkins
ISSN: 0959-4965
Last Modified: 02 May 2019 12:50

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