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[(ex)19.7(is)15.1(ti)20.6(ng)-497.5(ne)19.7(ut)20.7(ra)19.7(li)20.6(zi)19.5(ng)-497.5(an)19.7(ti)20.6(bo)15.1(di)20.7(es)-498.5(in)-491.9(th)15(e)-503.4(p)0(o)20.8(p)0(u)20.8(l)0(a)13.8(t)0(i)20.6(o)0(n)20.8(,)]TJ
7.3823 0 0 6.5614 264.3023 477.4676 Tm
-.0162 Tc
(19)Tj
9.843 0 0 9.843 276.5479 473.1022 Tm
0 Tc
[(up)-497.5(to)]TJ
-22.0251 -1.1174 TD
-.0203 Tc
[(8)-20.3(0)-5.2(%)-281.6(s)-20.3(er)-20.3(op)-20.3(re)-20.3(va)-20.3(le)-20.3(nc)-20.3(e)-272.5(i)-20.3(n)-276.1(s)-20.3(om)-20.3(e)-272.6(s)-20.3(tu)-20.3(di)-20.3(es)-20.3(,)]TJ
7.3823 0 0 6.5614 203.0173 466.5258 Tm
0 Tc
(20)Tj
9.843 0 0 9.843 212.8818 462.1038 Tm
[(wh)20(ic)19.6(h)-266(m)15(ay)-256.8(re)19.7(du)20.8(ce)-252.2(th)20.7(e)]TJ
-15.557 -1.1116 TD
[(ef)14(c)19.8(ac)18.5(y)-531(o)0(f)-520.5(t)0(r)20.7(a)0(n)19.7(s)0(g)21(e)0(n)19.7(e)-532.1(ex)19.7(pr)20.9(es)14.1(si)20.9(on)20.8(,)]TJ
7.3823 0 0 6.5614 194.7968 455.5274 Tm
-.0162 Tc
(21)Tj
9.843 0 0 9.843 207.2692 451.1621 Tm
0 Tc
[(al)19.5(th)15(ou)20.8(gh)-520.6(th)20.7(e)-532.1(e)0(f)19.7(f)0(e)19.7(c)0(t)-521.9(o)0(f)]TJ
-14.9868 -1.1116 TD
-.0196 Tc
[(p)-19.6(r)-4.5(e)-19.6(e)-1.1(x)-19.6(i)1.1(s)-19.6(t)1.3(i)-19.6(n)1.1(g)-475.7(n)-19.6(eu)-19.6(tr)-19.6(al)-19.6(iz)-19.6(in)-19.6(g)-465.3(a)-19.6(nt)-19.6(ib)-19.6(od)-19.6(ie)-19.6(s)-466.3(o)-19.6(n)-459.5(a)-19.6(de)-19.6(no)-19.6(vi)-19.6(ru)-19.6(s)-459.3(t)-19.6(ra)-19.6(ns)-19.6(du)-19.6(c-)]TJ
T*
0 Tc
[(ti)14.8(on)-272.9(in)-278.8(th)20.7(e)-284.5(C)0(A)18.9(B)0(G)-280.6(s)0(e)19.9(t)0(t)20.6(i)0(n)20.7(g)-289.1(is)-272.8(un)15.1(kn)20.8(ow)20(n)-283.3(a)0(s)-279.6(g)0(e)19.7(n)0(e)-279.8(t)0(r)20.7(a)0(n)19.7(s)0(f)21.1(e)0(r)-279.8(o)0(c)19.7(c)0(u)19.7(r)0(s)]TJ
/F6 1 Tf
0 -1.1174 TD
[(ex)-229.2(vi)19.5(vo)]TJ
/F5 1 Tf
2.7589 0 TD
[(.)-239.6(T)0(o)19.6(g)0(e)19.7(t)0(h)20.7(e)0(r)19.7(,)-239.6(th)20.7(es)19.9(e)-238.4(l)0(i)20.6(m)0(i)19.5(t)0(a)19.6(t)0(i)20.6(o)0(n)15.1(s)-237(of)-226.8(Ad)20(5)-237.2(s)0(u)21(g)0(g)20.8(e)0(s)19.9(t)-237.4(th)20.7(at)19.5(,)-239.6(w)0(h)20(i)0(l)20.6(e)]TJ
-2.7589 -1.1116 TD
[(th)15(e)-365.1(v)0(e)19.7(c)0(t)19.5(o)0(r)-353.5(m)0(a)18.4(y)-364(be)-360.5(su)21(it)20.6(ab)19.7(le)-360.6(fo)20.9(r)-363.9(h)0(u)20.8(m)0(a)18.4(n)-364(CA)18.9(BG)-361.2(ge)19.7(ne)-354.7(th)20.7(er)19.7(ap)19.7(y,)]TJ
T*
[(al)19.5(te)13.8(rn)20.9(at)19.5(iv)20.7(e)-324.8(v)0(e)19.7(c)0(t)19.5(o)0(r)20.9(s)-323.4(mi)19.5(gh)20.8(t)-323.8(p)0(r)15.1(o)0(v)20.8(i)0(d)20.7(e)-324.8(im)19.5(pr)20.9(ov)20.8(ed)-314.4(op)20.8(po)20.8(rt)20.7(un)15.1(it)20.6(ie)19.6(s.)]TJ
1.0137 -1.1174 TD
[(To)-711.8(in)20.7(cr)19.7(ea)18.5(se)-705.8(tr)15(an)19.7(sg)21(en)19.7(e)-716.5(e)0(x)13.9(p)0(r)20.9(e)0(s)19.9(s)0(i)20.9(o)0(n)-710.6(i)0(n)-705(t)0(h)20.7(e)-722.2(va)19.7(sc)19.9(ul)20.7(at)19.6(ur)20.9(e,)]TJ
-1.0137 -1.1116 TD
[(ps)15.3(eu)19.7(do)20.8(ty)20.7(pi)20.7(ng)-566.6(of)-572.4(Ad)20(5)-577.1(h)0(a)19.7(s)-576.9(be)19.7(en)-567.8(sh)21(ow)14.2(n)-577.1(t)0(o)-566.8(b)0(e)-567.8(e)0(f)19.7(f)0(e)19.7(c)0(t)19.5(i)0(v)20.7(e)0(.)]TJ
7.3823 0 0 6.5614 291.5716 378.8219 Tm
(22)Tj
9.843 0 0 9.843 59.7543 363.5149 Tm
[(Se)14.1(ve)19.7(ra)19.7(l)-266.2(s)0(u)21(b)0(g)20.8(r)0(o)20.9(u)0(p)-255.6(B)-267.1(ad)19.7(en)19.7(ov)20.8(ir)15(us)21(es)19.9(,)-268.4(i)0(n)20.7(c)0(l)19.5(u)0(d)20.8(i)0(n)20.7(g)-266(Ad)20(35)20.8(,)-268.4(u)0(s)21(e)-267.2(CD)18.9(46)]TJ
0 -1.1174 TD
[(as)-579.1(a)-584(r)0(e)19.7(c)0(e)18.5(p)0(t)14.9(o)0(r)20.9(,)]TJ
7.3823 0 0 6.5614 117.7511 356.9385 Tm
(23)Tj
9.843 0 0 9.843 130.8472 352.5164 Tm
[(wh)20(ic)19.6(h)-582.8(i)0(s)-578.1(r)0(e)19.7(l)0(a)19.6(t)0(i)20.6(v)0(e)13.9(l)0(y)-572.5(h)0(i)20.7(g)0(h)20.8(l)0(y)-578.3(e)0(x)19.7(p)0(r)20.9(e)0(s)19.9(s)0(e)14.1(d)-582.8(on)]TJ
-7.2227 -1.1116 TD
[(VS)14.4(MC)18.9(s,)-240.5(an)19.7(d)-248.8(c)0(h)19.7(i)0(m)19.5(e)0(r)19.7(i)0(c)-245.4(A)0(d)20(5)0(/)20.7(A)0(d)20(3)0(5)-244.1(v)0(i)20.7(r)0(u)20.9(s)0(e)19.9(s)-254.3(sh)21(ow)-239.2(mo)19.6(re)-245.2(ef)19.7(c)19.8(ie)19.6(nt)]TJ
T*
[(ge)19.7(ne)-400.8(tr)20.7(an)19.7(sf)15.3(er)-395(to)-399.7(th)20.7(e)-405.4(v)0(a)19.7(s)0(c)19.9(u)0(l)14.9(a)0(t)19.5(u)0(r)20.9(e)-405.4(th)20.7(an)-400.8(Ad)20(5.)]TJ
7.3823 0 0 6.5614 230.8535 334.9983 Tm
-.0162 Tc
(17)Tj
9.843 0 0 9.843 242.1354 330.633 Tm
0 Tc
[(An)-394.7(al)13.8(te)19.6(rn)20.9(at)19.6(iv)20.7(e)]TJ
-18.529 -1.1116 TD
[(st)15.1(ra)19.7(te)19.6(gy)-416.9(is)-416.8(ex)19.7(pl)14.9(oi)20.7(ta)19.6(ti)20.6(on)-416.9(of)-416.9(th)20.7(e)-428.5(n)0(a)13.9(t)0(u)20.7(r)0(a)19.7(l)-427.4(tr)20.7(op)20.8(is)15.1(m)-422.8(o)0(f)-422.6(n)0(o)20.8(v)0(e)19.7(l)-427.4(Ad)]TJ
0 -1.1174 TD
[(se)14.1(ro)20.9(ty)20.7(pe)19.7(s.)-269.3(Su)21(bg)20.8(ro)20.9(up)-267.1(D)-278.4(a)0(d)19.7(e)0(n)19.7(o)0(v)20.8(i)0(r)20.7(u)0(s)15.3(e)0(s)-268.1(v)0(a)19.7(r)0(y)-267.1(i)0(n)-267.3(r)0(e)19.7(c)0(e)18.5(p)0(t)20.7(o)0(r)-267.1(u)0(s)21(e)-278.7(an)19.7(d)]TJ
0 -1.1116 TD
[(tr)15(op)20.8(is)20.9(m;)-291.5(so)15.3(m)15(e)-307.5(in)20.7(fe)19.7(ct)-291.5(ce)12.8(ll)20.6(s)-300.4(b)0(y)-295.9(b)0(i)20.7(n)0(d)20.8(i)0(n)20.7(g)-300.6(CA)18.9(R,)-293.6(wh)14.2(il)20.6(e)-301.8(o)0(t)20.7(h)0(e)19.7(r)0(s)-295.7(u)0(s)21(e)]TJ
T*
[(CD)18.9(46)]TJ
7.3823 0 0 6.5614 82.885 291.1747 Tm
-.0162 Tc
(24)Tj
9.843 0 0 9.843 94.6771 286.8094 Tm
0 Tc
[(or)-451.4(si)15.1(al)19.6(ic)-452.7(ac)18.5(id)20.7(.)]TJ
7.3823 0 0 6.5614 150.8031 291.1747 Tm
-.0162 Tc
(25)Tj
9.843 0 0 9.843 162.5952 286.8094 Tm
0 Tc
[(Ho)14.2(we)18.8(ve)19.7(r,)-448(th)20.7(e)-463(r)0(e)19.7(c)0(e)12.8(p)0(t)20.7(o)0(r)20.9(s)-461.7(fo)20.9(r)-461.8(m)0(a)18.4(n)0(y)]TJ
-10.4481 -1.1174 TD
[(su)15.3(bg)20.8(ro)20.9(up)-624.2(D)-635.5(a)0(d)19.7(e)0(n)19.7(o)0(v)20.8(i)0(r)20.7(u)0(s)21(e)0(s)-625.2(h)0(a)19.7(v)0(e)-625.4(n)0(o)20.8(t)-634.8(be)19.7(en)-625.4(id)20.7(en)19.7(ti)20.6(e)14.1(d,)-620.8(an)19.7(d)]TJ
0 -1.1116 TD
[(th)15(er)19.7(ef)19.7(or)20.9(e)-273(t)0(h)20.7(e)0(y)-262.5(m)0(a)18.4(y)-271.8(pr)20.9(ov)20.8(id)20.7(e)-273(n)0(e)19.7(w)-272.7(ve)19.7(ct)13.8(or)20.9(s)-271.6(f)0(o)20.9(r)-271.8(ge)19.7(ne)-262.5(th)20.7(er)19.7(ap)19.7(y.)-263.7(An)]TJ
T*
[(ad)19.7(di)15(ti)20.6(on)20.8(al)-337.6(cl)19.5(in)20.7(ic)19.5(al)-337.6(be)19.7(ne)19.7(t)-336.2(is)-336.2(th)20.7(at)-337.6(sp)21(ec)18.5(ie)13.8(s)-340.7(D)-347.5(ad)19.7(en)19.7(ov)15.1(ir)20.7(us)21(es)-337.2(ar)19.7(e)]TJ
0 -1.1174 TD
[(re)14(po)20.8(rt)20.7(ed)-320.1(to)-324.9(ha)19.7(ve)-320.1(lo)20.7(w)-330.3(s)0(e)14.1(r)0(o)20.9(p)0(r)20.9(e)0(v)19.7(a)0(l)19.5(e)0(n)19.7(c)0(e)-327.1(r)0(a)19.7(t)0(e)19.6(s)0(.)]TJ
7.3823 0 0 6.5614 227.3385 247.3511 Tm
-.0162 Tc
(24)Tj
9.843 0 0 9.843 237.8834 242.929 Tm
0 Tc
[(He)18.8(re)-320.1(we)-326.8(ev)19.7(al)19.5(u-)]TJ
-18.097 -1.1116 TD
[(at)19.5(ed)-435.3(a)-445.8(p)0(a)19.7(n)0(e)19.7(l)-444.7(of)-434.1(ad)19.7(en)13.9(ov)20.8(ir)20.7(us)21(es)-435.1(an)19.7(d)-444.6(h)0(i)20.7(g)0(h)20.8(l)0(i)14.8(g)0(h)20.8(t)-444.7(th)20.7(e)-445.8(e)0(f)19.7()0(c)19.8(a)0(c)18.5(y)-444.6(of)]TJ
T*
[(Ad)14.2(49)-307.5(as)-314.2(a)-324.8(v)0(e)19.7(c)0(t)13.8(o)0(r)-313.2(f)0(o)20.9(r)-323.6(va)19.7(sc)19.9(ul)20.7(ar)-314.4(ge)19.7(ne)-314.4(th)20.7(er)19.7(ap)19.7(y.)]TJ
/F1 1 Tf
8.9663 0 0 8.9663 59.7543 199.1054 Tm
[(Materials)-339(and)-331.9(Methods)]TJ
/F10 1 Tf
0 -1.8336 TD
[(Cells)-335.8(and)-335.7(tissue)]TJ
/F5 1 Tf
9.843 0 0 9.843 69.7323 166.2236 Tm
[(PER.C6)-363.4(cells)]TJ
7.3823 0 0 6.5614 123.4771 170.5889 Tm
(26)Tj
9.843 0 0 9.843 134.4188 166.2236 Tm
[(\(kind)-362.7(gift)-361.7(from)-362.7(Jerome)-367(Custers,)-364.4(Crucell\))]TJ
-7.5855 -1.1116 TD
[(and)-309.7(HEK293)-303.3(cells)-307.4(\(human)-308.5(embryonic)-307.3(kidney:)-308.6(ATCC)-308(CRL-)]TJ
T*
[(1573\))-339.5(were)-335.9(used)-339.4(for)-337.3(viral)-335.2(propagation)-337.2(and)-338.5(cultured)-339.7(in)-336.4(Dul-)]TJ
0 -1.1174 TD
[(beccos)-633(modied)-626.4(Eagles)-633.2(medium)-626.6(\(DMEM;)-632.6(Invitrogen\))]TJ
0 -1.1116 TD
[(with)-552.7(2)-162.4(m)]TJ
/F6 1 Tf
3.7784 0 TD
(M)Tj
/F5 1 Tf
1.3823 0 TD
[(L-glutamine)-552.9(\(Invitrogen\))-550.2(and)-545.9(10%)-545.8(fetal)-555.2(calf)]TJ
-5.1607 -1.1116 TD
[(serum)-272.6(\(FCS;)-271.3(PAA)-269.8(Laboratories\))-272.4(with)-270.5(the)-269.5(addition)-269.6(of)-267.1(10)-169.2(m)]TJ
/F6 1 Tf
23.4593 0 TD
(M)Tj
/F5 1 Tf
-23.4593 -1.1174 TD
(MgCl)Tj
7.3823 0 0 6.5614 82.7716 98.8157 Tm
(2)Tj
9.843 0 0 9.843 90.6519 100.4598 Tm
[(\(Sigma-Aldrich\))-435.8(for)-429.5(PER.C6)-426.7(cells.)-431.8(Hep)-431.6(G2)-429.3(\(hepa-)]TJ
-3.139 -1.1116 TD
[(tocellular)-337.5(carcinoma:)-339.7(ATCC)-331.1(HB-8065\),)-336.6(A549)-327.8(\(human)-337.3(lung)]TJ
T*
[(carcinoma:)-351.2(ATCC)-348.4(CCL-185\),)-343.8(and)-344.3(SKOV3)-347.8(\(human)-343(ovarian)]TJ
0 -1.1174 TD
[(carcinoma:)-333.9(ATCC)-325.3(HTB-77\))-327.5(cells)-324.7(were)-330.1(cultured)-328.1(in)-319.1(minimal)]TJ
0 -1.1116 TD
[(essential)-359(medium)-355.9(\()-81.7(MEM\))-353(or)-353.5(RPMI-1640)-357.2(medium)-350.2(\(Invitro-)]TJ
25.5097 67.9184 TD
[(gen\),)-308.5(with)-305(2)-168.1(m)]TJ
/F6 1 Tf
5.8691 0 TD
(M)Tj
/F5 1 Tf
1.1404 0 TD
[(L-glutamine,)-308.6(10%)-309.6(FCS,)-307(and)-304(1)-168.1(m)]TJ
/F6 1 Tf
13.1955 0 TD
(M)Tj
/F5 1 Tf
1.1347 0 TD
(sodium)Tj
-21.3397 -1.1174 TD
[(pyruvate)-443.2(\(Sigma-Aldrich\).)-439.2(Cells)-445.5(were)-439.5(maintained)-442.3(at)-441.2(37)]TJ
/F7 1 Tf
23.2289 0 TD
()Tj
/F5 1 Tf
.3974 0 TD
(C)Tj
-23.6263 -1.1116 TD
[(and)-390.4(5%)-389.2(CO)]TJ
7.3823 0 0 6.5614 359.4897 701.5746 Tm
(2)Tj
9.843 0 0 9.843 367.0298 703.2188 Tm
[(with)-391.4(the)-384.7(exception)-393.8(of)-388.1(PER.C6)-392.2(maintained)-396.3(in)]TJ
-5.7079 -1.1116 TD
[(10%)-349.9(CO)]TJ
7.3823 0 0 6.5614 345.9967 690.6329 Tm
(2)Tj
9.843 0 0 9.843 349.6818 692.277 Tm
[(.)-354.8(Human)-354.4(saphenous)-351.7(vein)-357(segments)-351.9(were)-358.9(obtained)]TJ
-3.9454 -1.1116 TD
[(from)-633.4(patients,)-636.8(who)-632(gave)-634.5(informed)-639.1(consent,)-635.5(undergoing)]TJ
0 -1.1174 TD
[(CABG.)-409.1(Ethics)-418(permission)-410.7(was)-414.1(obtained)-408.8(from)-414.5(the)-407.8(West)-416.7(of)]TJ
0 -1.1116 TD
[(Scotland)-414.4(Research)-423.2(Ethics)-418(Committee)-419.3(4)-410(\(reference)-419.9(number)]TJ
T*
[(10/S0704/60\).)-333.5(Serum)-336(samples)-333.5(were)-335.9(obtained,)-337.4(with)-333.8(consent,)]TJ
0 -1.1174 TD
[(from)-385.7(patients)-391.5(attending)-387(cardiovascular)-395.6(disease)-391.1(clinics)-390.4(with)]TJ
0 -1.1116 TD
[(ethics)-256.7(permission)-255.2(from)-259(the)-252.3(West)-255.4(Glasgow)-258.2(Ethics)-256.7(Committee)]TJ
T*
[(1)-329.4(\(reference)-339.2(number)-337.3(S/0703/110\).)]TJ
/F10 1 Tf
8.9663 0 0 8.9663 310.8472 591.8171 Tm
[(Smooth)-332.5(muscle)-335.3(and)-329.4(EC)-335.8(isolation)-334.1(and)-335.7(culturing)]TJ
/F5 1 Tf
9.843 0 0 9.843 320.8251 575.4329 Tm
[(VSMCs)-393.9(were)-399.2(isolated)-397.2(from)-391.5(human)-393.8(saphenous)-397.8(vein)-397.4(seg-)]TJ
-1.0137 -1.1174 TD
[(ments)-284.3(using)-281.9(the)-281.1(explant)-286.8(technique)-284.4(as)-285.4(previously)-282.9(described)]TJ
7.3823 0 0 6.5614 542.551 568.7999 Tm
(27)Tj
9.843 0 0 9.843 310.8472 553.4928 Tm
[(and)-511.3(cultured)-512.5(in)-509.2(SMC)-511.9(growth)-514.4(media)-510.3(2)-507.9(\(PromoCell\))-516.6(with)]TJ
0 -1.1116 TD
[(addition)-321.4(of)-324.7(provided)-326.9(supplement)-325.7(mix,)-324.9(10%)-321.1(FCS,)-324.2(and)-321.2(2)-168.1(m)]TJ
/F6 1 Tf
23.4593 0 TD
(M)Tj
/F5 1 Tf
-23.4593 -1.1174 TD
[(L-glutamine.)-256.8(ECs)-253(were)-249.5(isolated)-259(from)-247.5(human)-255.6(saphenous)-253.8(vein)]TJ
0 -1.1116 TD
[(segments)-386.5(by)-376.6(collagenase)-392.4(digestion)-379.9(as)-383.3(previously)-386.6(described)]TJ
T*
[(and)-378.8(cultured)-385.7(in)-382.5(Large)-383.4(Vessel)-383.9(Endothelial)-384.8(Cell)-387(Basal)-383.2(Med-)]TJ
0 -1.1174 TD
[(ium)-321.4(\(TCS)-323.2(CellWorks\))-326.5(with)-322.3(provided)-321.1(supplements)-326.6(and)-321.2(20%)]TJ
0 -1.1116 TD
[(FCS.)-272.4(Primary)-280.7(cell)-277.7(lines)-277.4(were)-278.3(used)-276.1(between)-277.1(passage)-275.8(3)-277.6(and)-275.2(6.)]TJ
/F10 1 Tf
8.9663 0 0 8.9663 310.8472 464.0314 Tm
[(Recombinant)-334.5(adenoviral)-331.9(vectors)]TJ
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[(All)-522.8(recombinant)-529.7(adenoviruses)-529(described)-531.7(in)-526.5(this)-528.6(article)]TJ
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T*
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[(viral)-243(particles)]TJ
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[(\(vp\))-303.8(and)-309.7(conrmed)-305.9(by)-307.5(nanosight)-304.9(measurement)-312.9(\(Nanosight\).)]TJ
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[(Infectious)-347.4(units)-345.4(\(pfu\))-339.5(were)-347.4(quantied)-346.4(by)-347.8(end-point)-345.4(dilution)]TJ
T*
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(30)Tj
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[(Transduction)-331(assays)-335.7(and)-335.7(neutralization)-334.1(assays)]TJ
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[(Cells)-451.3(were)-456.8(plated)-458.4(in)-451.6(96-well)-459.2(format,)-450.2(1)]TJ
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(4)Tj
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[(l)-473.5(serum-free)-482(media,)]TJ
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()Tj
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[(hFX)-476.3(\(8)]TJ
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(l)Tj
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[(g/ml\))-479.3(where)-475.2(stated.)-479(Cells)-474.3(were)-474.1(incubated)-480.2(with)]TJ
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[(virus)-310.7(for)-308.5(3)-168.1(h)0(r)-307.4(a)0(t)-308.8(3)0(7)]TJ
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7.6316 0 TD
()Tj
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[(C,)-310.8(unless)-312.8(otherwise)-312.7(stated;)-309.7(washed)-314.9(with)]TJ
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[(PBS;)-402.7(and)-407.6(maintained)-407.8(in)-405.5(standard)-408.5(medium)-407.8(until)-403.3(harvesting)]TJ
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[(with)-368.4(reporter)-374(lysis)-368.2(buffer)-370.5(\(RLB;)-371.7(Promega\))-375(48)-163.5(hr)-370.8(postinfec-)]TJ
T*
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[(luciferase)-320.9(assay)-318.5(\(Promega\))-318.5(and)-315.5(protein)-320.1(concentrations)-319.7(were)]TJ
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[(calculated)-414.6(by)-411.1(BCA)-415.2(\(ThermoFisher\))-417.2(assays)-411.5(were)-416.5(measured)]TJ
T*
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T*
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T*
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[(Sa)14.1(m)15(p)0(l)14.9(e)0(s)-590.7(w)0(e)18.8(r)0(e)]TJ
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T*
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T*
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/F1 1 Tf
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[(Ad49)-339.8(GENE)-330.5(THERAPY)-336.6(IN)-335.1(CORONARY)-340.5(ARTERY)-332.4(BYPASS)-338.7(GRAFTS)-21496.8(313)]TJ
ET
endstream
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[(Ex)-332.5(vivo)]TJ
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[(transduction)-335.2(of)-330.4(CABG)-336.8(tissue)]TJ
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T*
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25.504 13.9212 TD
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[(ve)13.9(in)-227(we)18.8(re)-233.7(ca)18.5(nn)20.8(ul)20.7(at)19.5(ed)19.7(,)-239.6(a)0(n)13.9(d)-237.2(th)20.7(e)-244.2(l)0(u)20.7(m)0(i)19.5(n)0(a)19.7(l)-237.4(su)15.3(rf)20.9(ac)18.5(e)-238.4(w)0(a)13.1(s)-237.1(ex)19.7(po)20.8(se)14.1(d)-237.2(t)0(o)]TJ
T*
[(ad)13.9(en)19.7(ov)20.8(ir)20.7(al)-222.4(ve)19.7(ct)19.5(or)20.9(s)-231.3(a)0(t)-222.4(1)]TJ
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(10)Tj
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(10)Tj
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(Immunohistochemistry)Tj
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(l)Tj
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[(m)-730.5(p)-19.7(ar)-19.7(a-)]TJ
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(M)Tj
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[(so)21(di)20.7(um)]TJ
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[(ci)13.8(tr)20.7(at)19.5(e)-319(b)0(u)20.8(f)0(f)20.9(e)0(r)-308.6(\()0(p)20.9(H)-318.7(6\))-307.4(an)19.7(d)-317.9(s)0(e)19.9(c)0(t)13.8(i)0(o)20.7(n)0(s)-307.3(w)0(e)18.8(r)0(e)-308.6(b)0(l)20.7(o)0(c)19.7(k)0(e)19.7(d)-317.9(in)-307.6(15)20.8(%)-318.9(g)0(o)20.8(a)0(t)]TJ
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[(se)14.1(ru)20.9(m)-497.7(b)0(e)19.7(f)0(o)20.9(r)0(e)-487.1(i)0(n)15(c)0(u)19.7(b)0(a)19.7(t)0(i)20.6(o)0(n)-486(w)0(i)19.8(t)0(h)-486.1(p)0(r)15.1(i)0(m)19.5(a)0(r)19.7(y)-496.4(an)19.7(ti)20.6(bo)20.8(di)14.9(es)19.9(:)-496.6(c)0(h)19.7(i)0(c)19.5(k)0(e)19.7(n)]TJ
ET
q
420.151 0 0 436.705 97.002 123.194 cm
/Im1 Do
Q
BT
/F8 1 Tf
9.845 0 0 9.845 62.022 106.4126 Tm
[(FIG.)-261.9(1.)]TJ
/F5 1 Tf
4.0367 0 TD
[(Tr)14.1(an)19.9(sd)21.2(uc)19.9(ti)20.7(on)-238.1(of)-238.1(pr)21(im)19.7(ar)19.9(y)-248.6(v)0(a)19.9(s)0(c)14.3(u)0(l)20.9(a)0(r)-239.3(c)0(e)18.7(l)0(l)20.7(s)0(.)-240.3(V)0(S)20.4(M)0(C)19.2(s)]TJ
/F8 1 Tf
19.0953 0 TD
[(\(A)20.2(\))]TJ
/F5 1 Tf
1.6124 0 TD
[(an)19.9(d)-248.6(E)0(C)18.9(s)]TJ
/F8 1 Tf
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[(\(B)20.1(\))]TJ
/F5 1 Tf
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[(we)19.1(re)-239.3(tr)20.9(an)19.9(sd)21.2(uc)19.9(ed)-239.3(wi)14.3(th)-232.5(10)15.3(,)13.9(0)0(0)21.1(0)-248.6(vp)21.1(/c)13.9(el)19.7(l)-248.8(o)0(f)-238.1(a)0(d)19.9(e)0(n)19.9(o)0(v)21.1(i)0(r)20.9(u)0(s)]TJ
-29.8753 -1.0135 TD
[(fo)21(r)-369.5(3)-156.5(hr)-359(at)-360.4(37)]TJ
/F7 1 Tf
5.4361 0 TD
()Tj
/F5 1 Tf
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[(C.)-356.6(Ce)18.9(ll)20.7(s)-369.4(w)0(e)19.1(r)0(e)-365.9(c)0(u)19.9(l)0(t)20.7(u)0(r)21.1(e)0(d)-360.2(f)0(o)21(r)-369.5(a)-370.7(f)0(u)21(r)0(t)15.1(h)0(e)19.9(r)-369.5(48)-145.9(hr)-359(be)19.9(fo)21.1(re)-360.2(an)19.9(al)19.7(ys)15.5(is)-359(of)-359(lu)20.9(ci)19.7(fe)19.9(ra)19.9(se)-365.8(tr)20.9(an)19.9(sg)21.2(en)19.9(e)-370.7(e)0(x)19.9(p)0(r)21(e)0(s)14.3(s)0(i)21(o)0(n)-359(w)0(a)19.1(s)-369.4(pe)19.9(rf)21.1(or)15.3(m)15.1(e)0(d)14.1(.)]TJ
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[(Re)18.9(pr)21.1(es)14.3(en)19.9(ta)19.7(ti)20.7(ve)-354.4(im)19.7(ag)19.9(es)-348.5(\(2)15.3(0)]TJ
/F7 1 Tf
10.8261 0 TD
()Tj
/F5 1 Tf
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[(\))-358(o)0(f)-353.3(V)0(S)20.4(M)0(C)19.2(s)-363.6(fo)21(ll)20.7(ow)14.5(in)20.9(g)-358(t)0(r)15.1(a)0(n)19.9(s)0(d)21.2(u)0(c)19.9(t)0(i)20.7(o)0(n)-353.3(o)0(f)-353.3(1)0(,)24.4(0)0(0)21(0)-363.8(\(1)21(k\))21.1(,)-366.2(5)0(,)24.4(0)0(0)15.3(0)-358(\(5)21(k\))15.3(,)-360.4(o)0(r)-353.3(1)0(0)21.1(,)13.9(00)15.3(0)-358(\()0(1)21(0)0(k)15.3(\))-358(vp)21.1(/c)19.7(el)13.9(l)-358.2(A)0(d)20.2(5)-363.8(or)]TJ
-11.5344 -1.0077 TD
[(Ad)20.2(49)21.1(G)20.2(FP)-237.7(ar)19.9(e)-244(s)0(h)21.2(o)0(w)20.2(n)-248.6(in)]TJ
/F8 1 Tf
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[(\(C)20.2(\))]TJ
/F5 1 Tf
1.3533 0 TD
[(.)-245.2(F)0(A)20.4(C)0(S)-233.1(a)0(n)19.9(a)0(l)19.7(y)0(s)15.5(i)0(s)-232.3(o)0(f)-232.3(G)0(F)20.4(P)-248.4(ex)19.9(pr)21.1(es)20(si)21(on)-238.1(48)-145.9(hr)-232.3(po)21.1(st)21(tr)20.9(an)14.1(sd)21.2(uc)19.9(ti)20.7(on)-232.3(in)-238.3(hV)20.2(SM)20.4(CS)]TJ
/F8 1 Tf
28.1593 0 TD
[(\(D)20.2(\))]TJ
/F5 1 Tf
1.6066 0 TD
[(an)19.9(d)-248.6(E)0(C)18.9(s)]TJ
/F8 1 Tf
3.5645 0 TD
[(\(E)20.1(\))]TJ
/F5 1 Tf
1.3014 0 TD
.2452 Tc
[(.D)245.2(a)264.3(t)245.2(a)11.5(a)245.2(r)265.1(e)]TJ
-45.9762 -1.0135 TD
0 Tc
[(me)18.7(an)]TJ
/F7 1 Tf
2.3034 0 TD
(+)Tj
/F5 1 Tf
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[(SE)-504(co)19.9(mp)19.9(ar)19.9(ed)-498.4(wi)20.1(th)-503.2(Ad)20.2(5)-507.7(b)0(y)-503(o)0(n)21.1(e)0(-)19.9(w)0(a)19.1(y)-513.5(AN)19.4(OV)19.4(A)-508.6(w)0(i)20.1(t)0(h)-503.1(D)0(u)20.2(n)0(n)21.1(e)0(t)19.7(t)0()20.9(s)]TJ
/F6 1 Tf
26.6333 0 TD
[(po)21.1(st)21(-h)21(oc)]TJ
/F5 1 Tf
3.887 0 TD
[(an)19.9(al)19.7(ys)21.2(is)-503(or)-497.2(St)15.3(ud)21(en)19.9(t)20.9(s)]TJ
/F6 1 Tf
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(t)Tj
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[(-t)20.9(es)20(t;)-503.3(**)]TJ
/F6 1 Tf
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(p)Tj
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(<)Tj
/F5 1 Tf
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[(0.)24.4(01)15.3(,)]TJ
-47.8305 -1.0135 TD
[(**)21.1(*)]TJ
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(p)Tj
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[(0.)18.7(00)21.1(1.)-315.3(Ad)20.2(5,)-315.3(ad)19.9(en)19.9(ov)21.1(ir)20.9(us)-312.8(se)20(ro)15.3(ty)20.9(pe)-314.1(5;)-313.1(EC)18.9(s,)-309.4(en)14.1(do)21.1(th)20.9(el)19.7(ia)19.7(l)-323.6(c)0(e)18.7(l)0(l)20.7(s)0(;)-312.9(v)0(p)21(,)-325.9(vi)20.9(ra)19.9(l)-323.7(p)0(a)19.9(r)0(t)15.1(i)0(c)19.7(l)0(e)19.7(s)0(;)-313(V)0(S)20.4(M)0(C)19.2(s)0(,)-315.2(v)0(a)19.9(s)0(c)20.1(u)0(l)20.9(a)0(r)-314.1(s)0(m)20.1(o)0(o)21.1(t)0(h)-318.9(m)15.1(us)15.5(cl)19.7(e)-324.6(c)0(e)18.7(l)0(l)20.7(.)]TJ
/F1 1 Tf
8.9663 0 0 8.9663 62.022 749.6502 Tm
(314)Tj
47.9466 0 TD
[(DAKIN)-337.3(ET)-338.7(AL.)]TJ
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