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β-Lactamase production in key gram-negative pathogen isolates from the Arabian Peninsula

Zowawi, H., Balkhy, H, Walsh, Timothy Rutland and Paterson, D. 2013. β-Lactamase production in key gram-negative pathogen isolates from the Arabian Peninsula. Clinical Microbiology Reviews 26 (3) , pp. 361-380. 10.1128/CMR.00096-12

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Infections due to Gram-negative bacilli (GNB) are a leading cause of morbidity and mortality worldwide. The extent of antibiotic resistance in GNB in countries of the Gulf Cooperation Council (GCC), namely, Saudi Arabia, United Arab Emirates, Kuwait, Qatar, Oman, and Bahrain, has not been previously reviewed. These countries share a high prevalence of extended-spectrum-β-lactamase (ESBL)- and carbapenemase-producing GNB, most of which are associated with nosocomial infections. Well-known and widespread β-lactamases genes (such as those for CTX-M-15, OXA-48, and NDM-1) have found their way into isolates from the GCCstates. However, less common and unique enzymes have also been identified. These include PER-7, GES-11, and PME-1. Several potential risk factors unique to the GCC states may have contributed to the emergence and spread of β-lactamases, including the unnecessary use of antibiotics and the large population of migrant workers, particularly from the Indian subcontinent. It is clear that active surveillance of antimicrobial resistance in the GCC states is urgently needed to address regional interventions that can contain the antimicrobial resistance issue.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Uncontrolled Keywords: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactam Resistance; beta-Lactamases; Carbapenems; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Middle East; Public Health Surveillance
Publisher: American Society for Microbiology
ISSN: 0893-8512
Last Modified: 04 Jun 2017 08:44

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