Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Environmental enrichment facilitates long-term potentiation in embryonic striatal grafts

Mazzocchi-Jones, D., Döbrössy, M. and Dunnett, Stephen Bruce 2010. Environmental enrichment facilitates long-term potentiation in embryonic striatal grafts. Neurorehabilitation and Neural Repair 25 (6) , pp. 548-557. 10.1177/1545968311402090

Full text not available from this repository.


Background. Housing animals in an enriched environment improves motor and cognitive performance and anatomical connectivity in rodent lesion models of Huntington disease and transplantation of embryonic striatal grafts. Objective. The authors evaluate the extent to which environmental enrichment can modify synaptic plasticity in the host-graft neuronal circuitry to try to find a physiological substrate for the observed improvements. Methods. C57BL/6 mice, housed in enriched or standard environments, received unilateral quinolinic acid lesions of the striatum, followed by embryonic striatal grafts. Then, 3 months posttransplantation, synaptic physiology and plasticity were evaluated by extracellular recording from in vitro striatal slices. Results. Environmental enrichment had no effect on the chance of long-term depression (LTD) induction or expression of LTD from either normal or grafted striatum. In contrast, enrichment increased the chance of long-term potentiation (LTP) induction and level of expression associated with increased levels of brain-derived neurotrophic factor within both the intact and grafted striatum compared with levels in the striatum of animals housed in standard environments. Conclusions. Environmental enrichment induces changes in host-graft corticostriatal LTP, thus providing a potential physiological substrate for the enrichment-induced improvement in motor and cognitive performance. The effect may be mediated by modulation of the trophic environment in which the grafted cells develop and integrate.

Item Type: Article
Status: Published
Schools: Biosciences
Uncontrolled Keywords: striatal grafts, basal ganglia, synaptic plasticity, functional connections, environmental enrichment
Publisher: Sage
ISSN: 1545-9683
Last Modified: 04 Jun 2017 02:05

Citation Data

Cited 15 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item