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Handing on health to the next generation

Holmes, Elaine, MacIntyre, David, Modi, Neena and Marchesi, Julian Roberto 2016. Handing on health to the next generation. In: Holmes, Elaine, Nicholson, Jeremy K., Darzi, Ara W. and Lindon, John C. eds. Metabolic Phenotyping in Personalized and Public Healthcare, Academic Press, pp. 213-264. (10.1016/B978-0-12-800344-2.00008-2)

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In this chapter, the role of metabolic phenotyping is described in relation to the improved understanding of the complex biochemical processes that occur in the fetus and in early life. The reasons for the importance of this type of medical supervision are discussed, and the factors that operate both in utero and in the first stages of a baby’s life are given. The development of the metabolic phenotype as life begins and continues is explained, including the importance of symbiotic bacteria (the microbiome). The changing metabolic phenotyping in various conditions such as premature birth, maternal obesity, gestational diabetes, pre-eclampsia, and others is discussed in detail. Postnatal factors that influence ongoing health are then discussed in relation to metabolic processes. Finally, a strategy is proposed for monitoring infant and maternal health using metabolic phenotyping.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Academic Press
ISBN: 978-0-12-800344-2
Last Modified: 05 Jul 2019 13:15

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