Browse by Current Cardiff authors

Aubrey, Liam D., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Ulamec, Sabine M., Abramycheva, Natalia Y., Vasili, Eftychia, Devine, Oliver M., Wilkinson, Martin, Mackinnon, Eilish, Limorenko, Galina, Walko, Martin, Muwanga, Sarah, Amadio, Leonardo, Peters, Owen M. ORCID: https://orcid.org/0000-0002-6824-0663, Illarioshkin, Sergey N., Outeiro, Tiago F., Ranson, Neil A., Brockwell, David J., Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 and Radford, Sheena E. 2024. Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid. Proceedings of the National Academy of Sciences 121 (2) , e2309700120. 10.1073/pnas.2309700120

Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Kukharsky, Michail S. 2023. Editorial of the Special Issue: Recent advances in understanding of the role of synuclein family members in health and disease. Biomedicines 11 (9) , 2330. 10.3390/biomedicines11092330

Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Millership, Steven J., Peters, Owen M. ORCID: https://orcid.org/0000-0002-6824-0663, Connor-Robson, Natalie ORCID: https://orcid.org/0000-0001-8350-6928, Chaprov, Kirill, Kopylov, Arthur T., Montoya, Alex, Kramer, Holger, Withers, Dominic J. and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2021. β-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins. Journal of Biological Chemistry 297 (6) , 101375. 10.1016/j.jbc.2021.101375

Chaprov, Kirill, Rezvykh, Alexander, Funikov, Sergei, Ivanova, Tamara, Lysikova, Ekaterina, Deykin, Alexei, Kukharsky, Michail, Aksinenko, Alexey, Bachurin, Sergey, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Buchman, Vladimir ORCID: https://orcid.org/0000-0002-7631-8352 2021. A bioisostere of Dimebon/Latrepirdine delays the onset and slows the progression of pathology in FUS transgenic mice. CNS Neuroscience and Therapeutics 27 (7) , pp. 765-775. 10.1111/cns.13637

Guschina, Irina A., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Roman, Andrei, Pokrovskiy, Mikhail V. and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2021. Triple-knockout, synuclein-free mice display compromised lipid pattern. Molecules 26 (11) , 3078. 10.3390/molecules26113078

Hosford, Patrick S., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352, Smith, Jeffrey C., Marina, Nephtali and SheikhBahaei, Shahriar 2020. Synuclein deficiency results in age-related respiratory and cardiovascular dysfunctions in mice. Brain Sciences 10 (9) , 583. 10.3390/brainsci10090583

Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Tarasova, Tatiana V., Chaprov, Kirill D., Roman, Andrei Yu, Kukharsky, Michail S., Kolik, Larisa G., Ovchinnikov, Ruslan, Ustyugov, Aleksey A. ORCID: https://orcid.org/0000-0003-1977-4797, Durnev, Andrey D. and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2020. Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice. Neurobiology of Aging 91 , pp. 76-87. 10.1016/j.neurobiolaging.2020.02.026

Lysikova, Ekaterina A., Funikov, Sergei, Rezvykh, Alexander P., Chaprov, Kirill D., Kukharsky, Michail S., Ustyugov, Aleksey, Deykin, Alexey V., Flyamer, Ilya A., Boyle, Shelagh, Bachurin, Sergey O., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Buchman, Vladimir ORCID: https://orcid.org/0000-0002-7631-8352 2020. Low level of expression of C-terminally truncated human FUS causes extensive changes in the spinal cord transcriptome of asymptomatic transgenic mice. Neurochemical Research 45 , pp. 1168-1179. 10.1007/s11064-020-02999-z

Kukharsky, Michail S., Ninkina, Natalia N. ORCID: https://orcid.org/0000-0001-8570-5648, An, Haiyan, Telezhkin, Vsevolod, Wei, Wenbin, Rabesahala de Meritens, Camille, Cooper-Knock, Johnathan, Nakagawa, Shinichi, Hirose, Tetsuro, Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 and Shelkovnikova, Tatyana A. ORCID: https://orcid.org/0000-0003-1367-5309 2020. Long non-coding RNA Neat1 regulates adaptive behavioural response to stress in mice. Translational Psychiatry 10 , 171. 10.1038/s41398-020-0854-2

Lysikova, Ekaterina A, Kukharsky, Michail S, Chaprov, Kirill D, Vasilieva, Nataliia A, Roman, Andrei Y, Ovchinnikov, Ruslan K, Deykin, Alexey V, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Buchman, Vladimir L ORCID: https://orcid.org/0000-0002-7631-8352 2019. Behavioural impairments in mice of a novel FUS transgenic line recapitulate features of frontotemporal lobar degeneration. Genes, Brain and Behavior 18 (8) , e12607. 10.1111/gbb.12607

Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Kukharsky, Michail S, Hewitt, Maria V, Lysikova, Ekaterina A, Skuratovska, Larissa N, Deykin, Alexey V and Buchman, Vladimir ORCID: https://orcid.org/0000-0002-7631-8352 2019. Stem cells in human breast milk. Human Cell 32 (3) , pp. 223-230. 10.1007/s13577-019-00251-7

Roman, Andrei Yu., Devred, François, Byrne, Deborah, La Rocca, Romain, Ninkina, Natalia N. ORCID: https://orcid.org/0000-0001-8570-5648, Peyrot, Vincent and Tsvetkov, Philipp O. 2019. Zinc induces temperature-dependent reversible self-assembly of Tau. Journal of Molecular Biology 431 (4) , pp. 687-695. 10.1016/j.jmb.2018.12.008

Skvortsova, V.I., Bachurin, S.O., Ustyugov, A.A., Kukharsky, M.S., Deikin, A.V., Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 and Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 2018. Gamma-carbolines derivatives as promising agents for the development of pathogenic therapy for proteinopathy. Acta Naturae 10 (4) , pp. 59-62.

Garnier, Cyrille, Devred, Francois, Byrne, Deborah, Puppo, Remy, Roman, Andrei Yu., Malesinski, Soazig, Golovin, Andrey V., Lebrun, Regine, Ninkina, Natalia N. ORCID: https://orcid.org/0000-0001-8570-5648 and Tsvetkov, Philipp O. 2017. Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates. Scientific Reports 7 , 6812. 10.1038/s41598-017-07215-7

Roman, A. Yu., Kovrazhkina, E. A., Razinskaya, O. D., Kukharsky, M. S., Maltsev, A. V., Ovchinnikov, R. K., Lytkina, O. A., Smirnov, A. P., Moskovtsev, A. A., Borodina, Yu. V., Surguchov, A. P., Ustyugov, A. A., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Skvortsova, V. I. 2017. Detection of autoantibodies to potentially amyloidogenic protein, gamma-synuclein, in the serum of patients with amyotrophic lateral sclerosis and cerebral circulatory disorders. Доклады Академии Наук / Doklady Biochemistry and Biophysics 472 (1) , pp. 64-67. 10.1134/S1607672917010197

Roman, Andrei Yu, Limorenko, Galina, Ustyugov, Alexey A., Tarasova, Tatiana, Lysikova, Ekaterina A., Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 and Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 2017. Generation of mouse lines with conditionally or constitutively inactivated Snca gene and Rosa26-stop-lacZ reporter located in cis on the mouse chromosome 6. Transgenic Research 26 (2) , pp. 301-307. 10.1007/s11248-016-9995-8

Ludtmann, Marthe H. R., Angelova, Plamena R., Ninkina, Natalia N. ORCID: https://orcid.org/0000-0001-8570-5648, Gandhi, Sonia, Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 and Abramov, Andrey Y. 2016. Monomeric alpha-synuclein exerts a physiological role on brain ATP synthase. Journal of Neuroscience 36 (41) , pp. 10510-10521. 10.1523/JNEUROSCI.1659-16.2016

Connor-Robson, Natalie ORCID: https://orcid.org/0000-0001-8350-6928, Peters, Owen ORCID: https://orcid.org/0000-0002-6824-0663, Millership, Steven, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2016. Combinational losses of synucleins reveal their differential requirements for compensating age-dependent alterations in motor behavior and dopamine metabolism. Neurobiology of Aging 46 , pp. 107-112. 10.1016/j.neurobiolaging.2016.06.020

Fares, Mohamed-Bilal, Maco, Bohumil, Oueslati, Abid, Rockenstein, Edward, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352, Masliah, Eliezer and Lashuel, Hilal A. 2016. Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease. Proceedings of the National Academy of Sciences 113 (7) , E912-E921. 10.1073/pnas.1512876113

Machhada, Asif, Ang, Richard, Ackland, Gareth L., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352, Lythgoe, Mark F., Trapp, Stefan, Tinker, Andrew, Marina, Nephtali and Gourine, Alexander V. 2015. Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve. Heart Rhythm 12 (11) , pp. 2285-2293. 10.1016/j.hrthm.2015.06.005

Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Connor-Robson, Natalie ORCID: https://orcid.org/0000-0001-8350-6928, Ustyugov, Alexey A., Tarasova, Tatiana, Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309 and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2015. A novel resource for studying function and dysfunction of α-synuclein: mouse lines for modulation of endogenous Snca gene expression. Scientific Reports 5 , 16615. 10.1038/srep16615

Abramycheva, Natalya Y., Lysogorskaia, Elena V., Stepanova, Maria S., Zakharova, Maria N., Kovrazhkina, Elena A., Razinskaya, Olga D., Smirnov, Andrey P., Maltsev, Andrey V., Ustyugov, Alexey A., Kukharsky, Michail S., Khritankova, Inna V., Bachurin, Sergey O., Cooper-Knock, Johnathan, Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352, Illarioshkin, Sergey N., Skvortsova, Veronika I. and Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 2015. C9ORF72 hexanucleotide repeat expansion in ALS patients from the Central European Russia population. Neurobiology of Aging 36 (10) , 2908.e5-2908.e9. 10.1016/j.neurobiolaging.2015.07.004

Reed, Karen Ruth ORCID: https://orcid.org/0000-0002-7467-1718, Korobko, Igor, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Korobko, Elena V., Hopkins, Ben R., Platt, James L., Buchman, Vladimir ORCID: https://orcid.org/0000-0002-7631-8352 and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2015. Hunk/Mak-v is a negative regulator of intestinal cell proliferation. BMC Cancer 15 , 110. 10.1186/s12885-015-1087-2

Peters, Owen Morgan ORCID: https://orcid.org/0000-0002-6824-0663, Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Highley, John Robin, Cooper-Knock, Johnathan, Hortobágyi, Tibor, Troakes, Claire, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2015. Gamma-synuclein pathology in amyotrophic lateral sclerosis. Annals of Clinical and Translational Neurology 2 (1) , pp. 29-37. 10.1002/acn3.143

Robinson, Hannah, Deykin, Alexey V., Bronovitsky, Evgeny V., Ovchinnikov, Ruslan K., Ustyugov, Alexey A., Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Kukharsky, Michail S., Ermolkevich, Tatyana G., Goldman, Igor L., Sadchikova, Elena R., Kovrazhkina, Elena A., Bachurin, Sergey O., Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 and Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 2015. Early lethality and neuronal proteinopathy in mice expressing cytoplasm-targeted FUS that lacks the RNA recognition motif. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 16 (5-6) , pp. 402-409. 10.3109/21678421.2015.1040994

Surgucheva, Irina, He, Shuangteng, Rich, Megan C., Sharma, Ram, Ninkina, Natalia N. ORCID: https://orcid.org/0000-0001-8570-5648, Stahel, Philip F. and Surguchov, Andrei 2014. Role of synucleins in traumatic brain injury — An experimental in vitro and in vivo study in mice. Molecular and Cellular Neuroscience 63 , pp. 114-123. 10.1016/j.mcn.2014.10.005

Shelkovnikova, Tatyana A. ORCID: https://orcid.org/0000-0003-1367-5309, Robinson, Hannah K., Southcombe, Joshua A., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2014. Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms. Human Molecular Genetics 23 (19) , pp. 5211-5226. 10.1093/hmg/ddu243

Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Robinson, Hannah, Troakes, C., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Buchman, Vladimir ORCID: https://orcid.org/0000-0002-7631-8352 2014. Compromised paraspeckle formation as a pathogenic factor in FUSopathies. Human Molecular Genetics 23 (9) , pp. 2298-2312. 10.1093/hmg/ddt622

Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Ustiugov, A. A., Kokhan, V. S., Tarasova, T. V., Medvedeva, V. K., Khritankova, I. V., Bahcurin, S. O. and Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 2014. Study into molecular targets of a neuroprotective compound dimebon using a transgenic mice line. Biomeditsinskaia khimiia 60 (3) , pp. 354-363.

Bobkova, N. V., Garbuz, D. G., Nesterova, I., Medvinskaya, N., Samokhin, A., Alexandrova, I., Yashin, V., Karpov, V., Kukharsky, M. S., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Smirnov, A. A., Nudler, E. and Evgen'ev, M. 2014. Therapeutic effect of exogenous Hsp70 in mouse models of Alzheimer's disease. Journal of Alzheimer's Disease 38 (2) , pp. 425-435. 10.3233/JAD-130779

Deikin, A V, Kovrazhkina, E A, Ovchinnikov, R K, Bronovitskii, E V, Razinskia, O D, Smirnov, A P, Ermolkevich, T G, Eliakov, A B, Popov, A N, Fedorov, E N, Lytkina, O A, Kukharskii, M S, Tarasova, T V, Shelkovnikova, Tatyana A. ORCID: https://orcid.org/0000-0003-1367-5309, Ustiugov, A A, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Gol'dman, I L, Sadchikova, E R, Baruchin, S O and Skvortsova, V I 2014. A mice model of amyotrophic lateral sclerosis expressing mutant human FUS protein. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 114 (8) , pp. 62-69.

Cooper-Knock, Johnathan, Higginbottom, Adrian, Connor-Robson, Natalie ORCID: https://orcid.org/0000-0001-8350-6928, Bayatti, Nadhim, Bury, Joanna J., Kirby, Janine, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 and Shaw, Pamela J. 2013. C9ORF72 transcription in a frontotemporal dementia case with two expanded alleles. Neurology 81 (19) , pp. 1719-1721. 10.1212/01.wnl.0000435295.41974.2e

Garcia-Reitboeck, Pablo, Anichtchik, Oleg, Dalley, Jeffrey W., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Tofaris, George K., Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 and Spillantini, Maria Grazia 2013. Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra. Experimental Neurology 248 , pp. 541-545. 10.1016/j.expneurol.2013.07.015

Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Peters, Owen Morgan ORCID: https://orcid.org/0000-0002-6824-0663, Deykin, Alexey V., Connor-Robson, Natalie ORCID: https://orcid.org/0000-0001-8350-6928, Robinson, Hannah, Ustyugov, Aleksey ORCID: https://orcid.org/0000-0003-1977-4797, Bachurin, Sergey O., Ermolkevich, Tatyana G., Goldman, Igor L., Sadchikova, Elena R., Kovrazhkina, Elena A., Skvortsova, Veronica I., Ling, Shuo-Chien, Da Cruz, Sandrine, Parone, Philippe A., Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 and Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 2013. Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice. Journal of Biological Chemistry 288 (35) , pp. 25266-25274. 10.1074/jbc.M113.492017

Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352, Cooper-Knock, Johnathan, Connor-Robson, Natalie, Higginbottom, Adrian, Kirby, Janine, Razinskaya, Olga D., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Shaw, Pamela J. 2013. Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation. Molecular Neurodegeneration 8 (1) , 12. 10.1186/1750-1326-8-12

Shelkovnikova, T. A., Ustyugov, A. A., Kokhan, V. S., Tarasova, T. V., Medvedeva, V. K., Khrytankova, I. V., Bachurin, S. O. and Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 2013. Study into possible molecular targets of a neuroprotective compound dimebon using a transgenic mouse line. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 7 (2) , pp. 154-159. 10.1134/S1990750813020091

Peters, Owen Morgan ORCID: https://orcid.org/0000-0002-6824-0663, Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Tarasova, Tatiana, Springe, Signe, Kukharsky, Michail S., Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Kozin, Sergey A., Kotelevtsev, Yury, Bachurin, Sergey O., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2013. Chronic administration of dimebon does not ameliorate amyloid-β pathology in 5xFAD transgenic mice. Journal of Alzheimer's Disease 36 (3) , pp. 589-596. 10.3233/JAD-130071

Millership, Steven, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Guschina, Irina, Norton, Jessica, Brambilla, Riccardo ORCID: https://orcid.org/0000-0003-3569-5706, Oort, Pieter J., Adams, Sean H., Dennis, Rowena J., Voshol, Peter J., Rochford, Justin J. and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2013. Correction for Millership et al., Increased lipolysis and altered lipid homeostasis protect  -synuclein-null mutant mice from diet-induced obesity. Proceedings of the National Academy of Sciences of the United States of America 110 (13) , p. 5269. 10.1073/pnas.1302920110

Peters, Owen Morgan ORCID: https://orcid.org/0000-0002-6824-0663, Connor-Robson, Natalie ORCID: https://orcid.org/0000-0001-8350-6928, Sokolov, V. B., Aksinenko, A. Y., Kukharsky, M. S., Bachurin, S. O., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2013. Chronic administration of dimebon ameliorates pathology in Tau P301S transgenic mice. Journal of Alzheimer's Disease 33 (4) , pp. 1041-1049. 10.3233/JAD-2012-121732

Bachurin, S.O, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Tarasova, T.V, Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Kovrazhkina, E.A, Smirnov, A.P, Razinskaya, O and Skvortsova, V.I 2013. Modeling of lateral amyotrophic sclerosis: A non-genetic method. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova 113 (9) , pp. 86-89.

Millership, Steven, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Rochford, Justin J. and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2013. γ-synuclein is a novel player in the control of body lipid metabolism. Adipocyte 2 (4) , pp. 276-280. 10.4161/adip.25162

Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Peters, Owen Morgan ORCID: https://orcid.org/0000-0002-6824-0663, Connor-Robson, Natalie ORCID: https://orcid.org/0000-0001-8350-6928, Lytkina, Olga, Sharfeddin, Essam and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2012. Contrasting effects of α-Synuclein and γ-Synuclein on the phenotype of cysteine string protein α (CSPα) null mutant mice suggest distinct function of these proteins in neuronal synapses. Journal of Biological Chemistry 287 (53) , pp. 44471-44477. 10.1074/jbc.M112.422402

Millership, Steven, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Guschina, Irina, Norton, Jessica, Brambilla, Riccardo ORCID: https://orcid.org/0000-0003-3569-5706, Oort, Pieter J., Adams, Sean H., Dennis, Rowena J., Voshol, Peter J., Rochford, Justin J. and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2012. Increased lipolysis and altered lipid homeostasis protect γ-synuclein–null mutant mice from diet-induced obesity. Proceedings of the National Academy of Sciences of the United States of America 109 (51) , pp. 20943-20948. 10.1073/pnas.1210022110

Kokhan, V. S., Van'kin, G. I., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309 and Bachurin, S. O. 2012. Impaired spatial and working memory in ageing mice with targeted inactivation of α-synuclein gene. Doklady Biological Sciences 441 (1) , pp. 354-356. 10.1134/S0012496611060081

Peters, Owen Morgan ORCID: https://orcid.org/0000-0002-6824-0663, Millership, Steven, Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Soto, Ileana, Keeling, Lora, Hann, Anthona, Marsh-Armstrong, Nicholas, Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 and Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 2012. Selective pattern of motor system damage in gamma-synuclein transgenic mice mirrors the respective pathology in amyotrophic lateral sclerosis. Neurobiology of Disease 48 (1) , pp. 124-131. 10.1016/j.nbd.2012.06.016

Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2012. In Vivo properties of mutant FUS variants. Febs Journal 279 (Supp1) , p. 446. 10.1111/j.1742-4658.2010.08705.x

Kokhan, V. S., Bolkunov, A. V., Ustiugov, A. A., Van'kin, G. I., Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Redkozubova, O. M., Strekalova, T. V., Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Bachurin, S. O. 2012. Targeted inactivation of the gene encoding gamma-synuclein affects anxiety levels and investigative activity in mice. Neuroscience and Behavioral Physiology 42 (6) , pp. 575-581. 10.1007/s11055-012-9603-1

Bachurin, Sergey O., Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Ustyugov, Alexey A., Peters, Owen Morgan ORCID: https://orcid.org/0000-0002-6824-0663, Khritankova, Ina, Afanasieva, Marina A., Tarasova, Tatyana V., Alentov, Igor I., Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 and Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 2012. Dimebon slows progression of proteinopathy in γ-synuclein transgenic mice. Neurotoxicity Research 22 (1) , pp. 33-42. 10.1007/s12640-011-9299-y

Ustyugov, A. A., Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Kokhan, V. S., Khritankova, I. V., Peters, Owen Morgan ORCID: https://orcid.org/0000-0002-6824-0663, Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352, Bachurin, S. O. and Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 2012. Dimebon reduces the levels of aggregated amyloidogenic protein forms in detergent-insoluble fractions in vivo. Bulletin of Experimental Biology and Medicine 152 (6) , pp. 731-733. 10.1007/s10517-012-1618-7

Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Kulikova, A. A., Tsvetkov, Ph. O., Peters, Owen Morgan ORCID: https://orcid.org/0000-0002-6824-0663, Bachurin, S. O., Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 and Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 2012. Proteinopathies, neurodegenerative disorders with protein aggregation-based pathology. Molecular Biology 46 (3) , pp. 362-374. 10.1134/S0026893312020161

Anwar, Shabana, Peters, Owen Morgan ORCID: https://orcid.org/0000-0002-6824-0663, Millership, Steven, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Doig, N., Connor-Robson, Natalie ORCID: https://orcid.org/0000-0001-8350-6928, Threlfell, Sarah, Kooner, Gurdeep, Deacon, R., Bannerman, D., Bolam, J., Chandra, S., Cragg, Sarah, Wade- Martins, Richard and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2011. Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family. Journal of Neuroscience 31 (20) , pp. 7264-7274. 10.1523/JNEUROSCI.6194-10.2011

Guschina, Irina, Millership, Steven, O'Donnell, Valerie Bridget ORCID: https://orcid.org/0000-0003-4089-8460, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Harwood, John ORCID: https://orcid.org/0000-0003-2377-2612 and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2011. Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice. Lipids 46 (2) , pp. 121-130. 10.1007/s11745-010-3486-0

Skrovtsova, V. I., Bachurin, S. O., Razinskaia, O. D., Smirnov, A. P., Kovrazhkina, E. A., Pochigaeva, K. I., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309 and Ustigiuov, A. A. 2011. New aspects of the pathogenesis of lateral amyotrophic sclerosis. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova 111 (2) , pp. 4-9.

Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Ustyugov, A. A., Smirnov, A. P., Skvortsova, V. I., Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352, Bachurin, S. O. and Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 2011. FUS gene mutations associated with familiar forms of amyotrophic lateral sclerosis affect cellular localization and aggregation properties of the encoded protein. Doklady Biochemistry and Biophysics 438 (1) , pp. 123-126. 10.1134/S1607672911030045

Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Ustyugov, Alexey, Millership, Steven, Peters, Owen Morgan ORCID: https://orcid.org/0000-0002-6824-0663, Anichtchik, Oleg, Spillantini, Maria Grazia, Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352, Bachurin, Sergey and Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 2011. Dimebon does not ameliorate pathological changes caused by expression of truncated (1-120) human alpha-synuclein in dopaminergic neurons of transgenic mice. Neurodegenerative Diseases 8 (6) , pp. 430-437. 10.1159/000324989

Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309 2011. Targeted inactivation of gamma-synuclein gene affects anxiety and exploratory behaviour of mice. Zhurnal vysshe nervno deiatelnosti imeni I P Pavlova 6 (1) , pp. 85-93.

Korobko, Igor, Kalinichenko, Svetlana, Korobko, Elena, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Kiselev, Sergey and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2010. Pro-survival activity of the MAK-V protein kinase in PC12 cells [Letter]. Cell Cycle 9 (20) , pp. 4248-4249. 10.4161/cc.9.20.13592

Al-Wandi, Abdelmojib, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Millership, Steven, Williamson, S. J. M., Jones, P. A. and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2010. Absence of α-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice. Neurobiology of Aging 31 (5) , pp. 796-804. 10.1016/j.neurobiolaging.2008.11.001

Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Peters, Owen Morgan ORCID: https://orcid.org/0000-0002-6824-0663, Millership, Steven, Salem, Hatem Omar, Van der Putten, Herman and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2009. y-Synucleinopathy: neurodegeneration associated with overexpression of the mouse protein. Human Molecular Genetics 18 (10) , pp. 1779-1794. 10.1093/hmg/ddp090

Bachurin, S. O., Ustyugov, A. A., Peters, O., Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 and Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 2009. Hindering of proteinopathy-induced neurodegeneration as a new mechanism of action for neuroprotectors and cognition enhancing compounds. Doklady Biochemistry and Biophysics 428 (1) , pp. 235-238. 10.1134/S1607672909050032

Yamashita, M., Nonaka, T., Arai, T., Kametani, F., Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Bachurin, S. O., Akiyama, H., Goedert, M. and Hasegawa, M. 2009. Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models. FEBS Letters 583 (14) , pp. 2419-2424. 10.1016/j.febslet.2009.06.042

Senior, Steven, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Deacon, Robert, Bannerman, David, Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352, Cragg, Stephanie and Wade-Martins, Richard 2008. Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein. European Journal of Neuroscience 27 (4) , pp. 947-957. 10.1111/j.1460-9568.2008.06055.x

Mertsalov, I. B., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Wanless, J. S., Buchman, Vladimir ORCID: https://orcid.org/0000-0002-7631-8352, Korochkin, L. I. and Kulikova, D. A. 2008. Generation of mutant mice with targeted disruption of two members of the d4 gene family: neuro-d4 and cer-d4. Doklady Biochemistry and Biophysics 419 , pp. 65-68. 10.1134/S1607672908020051

Akil, O., Weber, C. M., Park, S. N., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Buchman, Vladimir ORCID: https://orcid.org/0000-0002-7631-8352 and Lustig, L. R. 2008. Localization of Syncleins in the Mammalian Cochlea. JARO-Journal of the Association for Research in Otolaryngology 9 (4) , pp. 452-463. 10.1007/s10162-008-0134-y

Buchman, Vladimir ORCID: https://orcid.org/0000-0002-7631-8352 and Ninkina, Natlia ORCID: https://orcid.org/0000-0001-8570-5648 2008. Modulation of α-synuclein expression in transgenic animals for modelling synucleinopathies-is the juice worth the squeeze? Neurotoxicity Research 14 (4) , pp. 329-341.

Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Ustiugov, A. A. and Buchman, Vladimir ORCID: https://orcid.org/0000-0002-7631-8352 2008. Modelling synucleinopathies in genetically modified animals - successes and failures. Molekulyarnaya Biologiya 42 (5) , 747 -761. 10.1134/S0026893308050129

Oort, P. J., Knotts, T. A., Grino, M., Naour, N., Bastard, J., Clement, K., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352, Permana, P. A., Luo, X., Pan, G., Dunn, T. N. and Adams, S. H. 2008. y-Synuclein is an Adipocyte-Neuron Gene Coordinately-Expressed with Leptin and Increased in Human Obesity. Journal of Nutrition 135 (5) , pp. 841-848.

Kuhn, Melanie, Haebig, Karina, Bonin, Michael, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352, Poths, Sven and Riess, Olaf 2007. Whole genome expression analyses of single- and double-knock-out mice implicate partially overlapping functions of alpha- and gamma-synuclein. Neurogenetics 8 (2) , pp. 71-81. 10.1007/s10048-007-0079-z

Korobko, I. V., Korobko, E. V., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 and Kiselev, S. L. 2007. Phosphorylation of MAK-V protein kinase in mammalian cells. Doklady Biochemistry and Biophysics 412 (1) , pp. 37-39. 10.1134/S1607672907010115

Papachroni, Katerina K., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Papapanagiotou, Angeliki, Hadjigeorgiou, Georgios M., Xiromerisiou, Georgia, Papadimitriou, Alexandros, Kalofoutis, Anastasios and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2006. Autoantibodies to alpha-synuclein in inherited Parkinson's disease. Journal of Neurochemistry 101 (3) , pp. 749-756. 10.1111/j.1471-4159.2006.04365.x

Surgucheva, Irina, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352, Grasing, Kenneth and Surguchov, Andrei 2005. Protein aggregation in retinal cells and approaches to cell protection. Cellular and Molecular Neurobiology 25 (6) , pp. 1051-1066. 10.1007/s10571-005-8474-1

Papachroni, Katerina, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Wanless, Julia, Kalofoutis, Anastasios Th., Gnuchev, Nikolai V. and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2005. Peripheral sensory neurons survive in the absence of α- and γ-synucleins. Journal of Molecular Neuroscience 25 (2) , pp. 157-164. 10.1385/JMN:25:2:157

Borthwick, Emma B., Korobkob, Igor V., Luke, Courtney, Drelc, Victor R., Fedyshyn, Yaroslav Ya., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Drobot, Ludmila B. and Buchman, Vladimir ORCID: https://orcid.org/0000-0002-7631-8352 2004. Multiple Domains of Ruk/CIN85/SETA/CD2BP3 are Involved in Interaction with p85α Regulatory Subunit of PI 3-kinase. Journal of Molecular Biology 343 (4) , pp. 1135-1146. 10.1016/j.jmb.2004.08.075

Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Papachroni, Katerina, Robertson, Darren C., Schmidt, Oliver, Delaney, Liz, O'Neill, Francis, Court, Felipe, Rosenthal, Arnon, Fleetwood-Walker, Susan M., Davies, Alun M. and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2003. Neurons Expressing the Highest Levels of γ-Synuclein Are Unaffected by Targeted Inactivation of the Gene. Molecular and Cellular Biology 23 (22) , pp. 8233-8245. 10.1128/MCB.23.22.8233-8245.2003

Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352, Luke, Courtney, Borthwick, Emma B., Gout, Ivan and Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 2002. Organization of the mouse Ruk locus and expression of isoforms in mouse tissues. Gene 295 (1) , pp. 13-17. 10.1016/S0378-1119(02)00821-1

Middleton, Gayle, Wyatt, Sean Lee ORCID: https://orcid.org/0000-0002-0572-234X, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Davies, Alun M. ORCID: https://orcid.org/0000-0001-5841-8176 2001. Reciprocal developmental changes in the roles of Bcl-w and Bcl-x(L) in regulating sensory neuron survival. Development 128 (3) , pp. 447-457.

Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Mertsalov, Ilja B., Kulikova, Dina A., Alimova-Kost, Maria V., Simonova, Olga B., Korochkin, Leonid I., Kiselev, Sergey L. and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2001. Cerd4, third member of the d4 gene family: expression and organization of genomic locus. Mammalian Genome 12 (11) , pp. 862-866. 10.1007/s00335-001-3039-1

Tiunova, A. A., Anokhin, K. V., Saha, A. R., Schmidt, O., Hanger, D. P., Anderton, B. H., Davies, A. M., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2000. Chicken synucleins: cloning and expression in the developing embryo. Mechanisms of Development 99 (1-2) , pp. 195-198. 10.1016/S0925-4773(00)00484-6

Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2000. Synucleins: to have or not to have? Russian Journal of Genetics 36 (11) , pp. 1487-1491.

Gout, I., Middleton, G., Adu, J., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Drobot, L. B., Filonenko, V., Matsuka, G., Davies, A. M., Waterfield, M. and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2000. Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein. Embo Journal 19 (15) , pp. 4015-4025.

Mertsalov, I. V., Kulikova, D. A., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Simonova, O. B., Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 and Korochkin, Ll. 2000. Genomic organization of the mouse neuro-d4 gene. Russian Journal of Genetics 3 (36) , pp. 241-244.