Browse by Current Cardiff authors

, Miners, Kelly L, Marsden, Morgan, Chapman, Lucy, Cardus Figueras, Anna, Scott, Jake, Andrews, Robert, Clare, Simon, Kriukova, Valeriia V, Lupyr, Ksenia R, Britanova, Olga V, Withers, David R, Jones, Simon A

, Chudakov, Dmitriy M, Price, David A

and Humphreys, Ian R

2023. Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1. eLife 12 , e79165. 10.7554/eLife.79165

Chen, Yi-Ling, Ng, Jessica Soo Weei, Ottakandathil Babu, Rosana, Woo, Jeongmin, Nahler, Janina, Hardman, Clare S., Kurupati, Prathiba, Nussbaum, Lea, Gao, Fei, Dong, Tao, Ladell, Kristin

, Duncan, David A., Johnson, David, Gileadi, Uzi, Koohy, Hashem and Ogg, Graham S. 2023. Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation. Science Immunology 8 (84) , eadd9232. 10.1126/sciimmunol.add9232

Ciacchi, Lisa, van de Garde, Martijn D.B., Ladell, Kristin

, Farenc, Carine, Poelen, Martien C.M., Miners, Kelly L., Llerena, Carmen, Reid, Hugh H., Petersen, Jan, Price, David A.

and van Els, Cécile A.C.M. 2023. CD4+ T cell-mediated recognition of a conserved cholesterol-dependent cytolysin epitope generates broad antibacterial immunity. Immunity 56 (5) , pp. 1082-1097. 10.1016/j.immuni.2023.03.020

Shepherd, Freya R., Davies, Kate

, Miners, Kelly L., Llewellyn-Lacey, Sian, Kollnberger, Simon, Redman, James E.

, Grant, Melissa M., Ladell, Kristin

and McLaren, James E.

2023. The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cells. Communications Biology 6 , 78. 10.1038/s42003-023-04420-1

Goncharov, Mikhail, Bagaev, Dmitry, Shcherbinin, Dmitrii, Zvyagin, Ivan, Bolotin, Dmitry, Thomas, Paul G., Minervina, Anastasia A., Pogorelyy, Mikhail V., Ladell, Kristin

, Nguyen, Thi H. O., Rowntree, Louise C., Clemens, E. Bridie, Kedzierska, Katherine, Dolton, Garry, Rius Rafael, Cristina

, Sewell, Andrew

, Samir, Jerome, Luciani, Fabio, Zornikova, Ksenia V., Khmelevskaya, Alexandra A., Sheetikov, Saveliy A., Efimov, Grigory A., Chudakov, Dmitry and Shugay, Mikhail 2022. VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2. Nature Methods 19 (9) , 1017–1019. 10.1038/s41592-022-01578-0

Fielding, Ceri Alan

, Sabberwal, Pragati, Williamson, James C., Greenwood, Edward J.D., Crozier, Thomas WM, Zelek, Wioleta, Seow, Jeffrey, Graham, Carl, Huettner, Isabella, Edgeworth, Jonathan D., Price, David A.

, Merrick, Blair, Doores, Katie, Wilson, Sam J., Lehner, Paul J., Wang, Eddie C.Y.

and Stanton, Richard J.

2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 10.7554/eLife.74489

Pymm, Phillip, Tenzer, Stefan, Wee, Edmund, Weimershaus, Mirjana, Burgevin, Anne, Kollnberger, Simon, Gerstoft, Jan, Josephs, Tracy M., Ladell, Kristin

, Appay, Victor, Price, David A.

, Fugger, Lars, Bell, John I., Schild, Hansjörg, van Endert, Peter, Harkiolaki, Maria and Iversen, Astrid K.N. 2022. Epitope length variants balance protective immune responses and viral escape in HIV-1 infection. Cell Reports 38 (9) , 110449. 10.1016/j.celrep.2022.110449

Campion, Suzanne L., Brenna, Elena, Thomson, Elaine, Fischer, Will, Ladell, Kristin

, Frahm, Nicole, McElrath, Juliana M., Cohen, Kristen W., Maenza, Janine R., Walsh, Stephen R., Baden, Lindsey R., Haynes, Barton F., Korber, Bette, Borrow, Persephone and McMichael, Andrew J. 2021. Preexisting memory CD4+ T cells contribute to the primary response in an HIV-1 vaccine trial. Journal of Clinical Investigation 131 (23) , e150823. 10.1172/JCI150823

Man, Stephen

, Redman, James E.

, Cross, Deborah L., Cole, David K.

, Can, Ilona, Davies, Bethan, Hashimdeen, Shaikh Shimaz, Reid, Reiss, Llewellyn-Lacey, Sian, Miners, Kelly L., Ladell, Kristin

, Lissina, Anya, Brown, Paul E., Wooldridge, Linda, Price, David A.

and Rizkallah, Pierre J.

2021. Synthetic peptides with inadvertent chemical modifications can activate potentially autoreactive T cells. The Journal of Immunology 207 (4) , pp. 1009-1017. 10.4049/jimmunol.2000756

Clement, Mathew

, Knezevic, Lea, Dockree, Tamsin, McLaren, James E.

, Miners, Kelly L., Llewellyn-Lacey, Sian, Rubina, Anzelika, Francis, Ore, Cole, David K.

, Bridgeman, John S., Price, David A.

, van den Berg, Hugo A. and Wooldridge, Linda 2021. CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor. Proceedings of the National Academy of Sciences 118 (29) , e2019639118. 10.1073/pnas.2019639118

Vlachava, Virginia-Maria

, Murrell, Isa, Zhuang, Lihui, Aicheler, Rebecca J., Lim, Eleanor, Miners, Kelly L., Ladell, Kristin

, Suárez, Nicolás M., Price, David A.

, Davison, Andrew J., Wilkinson, Gavin W.G., Wills, Mark R., Weekes, Michael P., Wang, Eddie C.Y.

and Stanton, Richard J.

2021. Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus. Journal of Clinical Investigation 131 (4) , e139296. 10.1172/JCI139296

Hanna, Stephanie J., Codd, Amy S., Gea-Mallorqui, Ester, Scourfield, D. Oliver, Richter, Felix C., Ladell, Kristin

, Borsa, Mariana, Compeer, Ewoud B., Moon, Owen R., Galloway, Sarah A.E., Dimonte, Sandra, Capitani, Lorenzo, Shepherd, Freya R., Wilson, Joseph D., Uhl, Lion F. K., Ahern, David J., Almuttaqi, Hannah, Alonzi, Dominic S., Alrubayyi, Aljawharah, Alsaleh, Ghada, Bart, Valentina M. T., Batchelor, Vicky, Bayliss, Rebecca, Berthold, Dorothée L., Bezbradica, Jelena S., Bharuchq, Tehmina, Borrmann, Helene, Borsa, Mariana, Borst, Rowie, Brun, Juliane, Burnell, Stephanie, Capitani, Lorenzo, Cavounidis, Athena, Chapman, Lucy, Chauveau, Anne, Cifuentes, Liliana, Codd, Amy Susan, Compeer, Ewoud Bernardus, Coveney, Clarissa, Cross, Amy, Danielli, Sara, Davies, Luke C., Dendrou, Calliope A., Dimonte, Sandra, Peter Durairaj, Ruban Rex, Dustin, Lynn B., Dyer, Arthur, Fielding, Ceri, Fischer, Fabian, Gallimore, Awen

, Galloway, Sarah, Gammage, Anís, Gea-Mallorquí, Ester, Godkin, Andrew, Hanna, Stephanie J., Heuberger, Cornelia, Hulin-Curtis, Sarah, Issa, Fadi, Jones, Emma, Jones, Ruth, Ladell, Kristin, Lauder, Sarah N., Liddiard, Kate, Ligoxygakis, Petros, Lu, Fangfang, MacLachlan, Bruce, Maleki-Toyserkani, Shayda, Mann, Elizabeth H., Marzeda, Anna M., Matthews, Reginald James, Mazet, Julie M., Milicic, Anita, Mitchell, Emma, Moon, Owen, Nguyen, Van Dien, O'Hanlon, Miriam, Eléonore Pavillet, Clara, Peppa, Dimitra, Pires, Ana, Pring, Eleanor, Quastel, Max, Reed, Sophie, Rehwinkel, Jan, Richmond, Niamh, Richter, Felix Clemens, Robinson, Alice J. B., Rodrigues, Patrícia R. S., Sabberwal, Pragati, Sami, Arvind, Peres, Raphael Sanches, Sattentau, Quentin, Schonfeldova, Barbora, Scourfield, David Oliver, Selvakumar, Tharini A., Shepherd, Freya R., Shorten, Cariad, Simon, Anna Katharina, Smith, Adrian L., Crespo, Alicia Teijeira, Tellier, Michael, Thornton, Emily, Uhl, Lion F. K., van Grinsven, Erinke, Wann, Angus K. T., Williams, Richard, Wilson, Joseph D., Zhou, Dingxi, Zhu, Zihan, Gallimore, Awen M. and Milicic, Anita 2021. T cell phenotypes in COVID-19 - a living review. Oxford Open Immunology 2 (1) 10.1093/oxfimm/iqaa007

Galletti, Giovanni, De Simone, Gabriele, Mazza, Emilia M.C., Puccio, Simone, Mezzanotte, Claudia, Bi, Timothy M., Davydov, Alexey N., Metsger, Maria, Scamardella, Eloise, Alvisi, Giorgia, Paoli, Federica De, Zanon, Veronica, Scarpa, Alice, Camisa, Barbara, Colombo, Federico S., Anselmo, Achile, Peano, Clelia, Polletti, Sara, Mavilio, Domenico, Gattinoni, Luca, Boi, Shannon K., Youngblood, Benjamin A., Jones, Rhiannon E., Baird, Duncan M.

, Gostick, Emma, Llewellyn-Lacey, Sian, Ladell, Kristin

, Chudakov, Dmitriy M., Newell, Evan W., Casucci, Monica and Lugli, Enrico 2020. Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans. Nature Immunology 21 , pp. 1552-1562. 10.1038/s41590-020-0791-5

Kasatskaya, Sofya A., Ladell, Kristin

, Egorov, Evgeniy S., Miners, Kelly L., Davydov, Alexey N., Metsger, Maria, Staroverov, Dmitry B., Matveyshina, Elena K., Shagina, Irina A., Mamedov, Ilgar Z., Izraelson, Mark, Shelyakin, Pavel V., Britanova, Olga V., Price, David A.

and Chudakov, Dmitriy M. 2020. Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs. eLife 9 , e57063. 10.7554/eLife.57063

Ahmed, Raya, Miners, Kelly L., Lahoz-Beneytez, Julio, Jones, Rhiannon E., Roger, Laureline, Baboonian, Christina, Zhang, Yan, Wang, Eddie C. Y.

, Hellerstein, Marc K., McCune, Joseph M., Baird, Duncan M.

, Macallan, Derek C., Asquith, Becca and Ladell, Kristin

2020. CD57+ Memory T Cells Proliferate In Vivo. Cell Reports 33 (11) , 108501. 10.1016/j.celrep.2020.108501

Narayanan, Gitanjali A., McLaren, James E.

, Meermeier, Erin W., Ladell, Kristin

, Swarbrick, Gwendolyn M., Price, David A.

, Tran, Jessica G., Worley, Aneta H., Vogt, Todd, Wong, Emily B. and Lewinsohn, David M 2020. The MAIT TCRβ chain contributes to discrimination of microbial ligand. Immunology and Cell Biology 98 (9) , pp. 770-781. 10.1111/imcb.12370

Hanna, Stephanie J., Powell, Wendy E.

, Long, Anna E., Robinson, Emma J. S., Davies, Joanne, Megson, Clare, Howell, Alexandra, Jones, Taz J., Ladell, Kristin

, Dayan, Colin M.

, Williams, Alistair J. K., Gillespie, Kathleen M. and Wong, F. Susan

2020. Slow progressors to type 1 diabetes lose islet autoantibodies over time, have few islet antigen-specific CD8+ T cells and exhibit a distinct CD95hi B cell phenotype. Diabetologia 63 , pp. 1174-1185. 10.1007/s00125-020-05114-7

Pearson, Frances E., Tullett, Kirsteen M., Leal-Rojas, Ingrid M., Haigh, Oscar L., Masterman, Kelly-Anne, Walpole, Carina, Bridgeman, John S., McLaren, James E.

, Miners, Kelly, Llewellyn-Lacey, Sian, Price, David A.

, Tunger, Antje, Schmitz, Marc, Miles, John J, Lahoud, Mireille H and Radford, Kristen J 2020. Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1‐specific CD8+ T cells. Clinical and Translational Immunology 9 10.1002/cti2.1141

Edwards, Sarah C., Sutton, Caroline E., Ladell, Kristin

, Grant, Emma J., McLaren, James E.

, Roche, Fiona, Dash, Pradyot, Apiwattanakul, Nopporn, Awad, Walid, Miners, Kelly L., Lalor, Stephen J., Ribot, Julie C., Baik, Song, Moran, Barry, McGinley, Aoife, Pivorunas, Valerie, Dowding, Lori, Macoritto, Michael, Paez-Cortez, Jesus, Slavin, Anthony, Anderson, Graham, Silva-Santos, Bruno, Hokamp, Karsten, Price, David A.

, Thomas, Paul G., McLoughlin, Rachel M. and Mills, Kingston H.G. 2020. A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans. Journal of Experimental Medicine 217 (5) , e20190834. 10.1084/jem.20190834

Starke, Carly E., Vinton, Carol L., Ladell, Kristin

, Ortiz, Alexandra M., Mudd, Joseph C., Flynn, Jacob K., Lai, Stephen H., Wu, Fan, Hirsch, Vanessa M., Darko, Samuel, Douek, Daniel C., Price, David A.

and Brenchley, Jason M. 2020. SIV-specific CD8+ T cells are clonotypically distinct across lymphoid and mucosal tissues. Journal of Clinical Investigation 130 (2) , pp. 789-798. 10.1172/JCI129161

Brenna, Elena, Davydov, Alexey N., Ladell, Kristin

, Bonaiuti, Paolo, Metsger, Maria, Ramsden, James D., Gilbert, Sarah C., Lambe, Teresa, Price, David A.

, Campion, Suzanne L., Chudakov, Dmitriy M., Borrow, Persephone and McMichael, Andrew J. 2020. CD4+ T follicular helper cells in human tonsils and blood are clonally convergent but divergent from Non-Tfh CD4+ cells. Cell Reports 30 (1) , pp. 137-152. 10.1016/j.celrep.2019.12.016

Smith, Corinne J., Venturi, Vanessa, Quigley, Maire F., Turula, Holly, Gostick, Emma, Ladell, Kristin

, Hill, Brenna J., Himelfarb, Danielle, Quinn, Kylie M., Greenaway, Hui Yee, Dang, Thurston H. Y., Seder, Robert A., Douek, Daniel C., Hill, Ann B., Davenport, Miles P., Price, David A.

and Snyder, Christopher M. 2020. Stochastic expansions maintain the clonal stability of CD8+ T cell populations undergoing memory inflation driven by murine cytomegalovirus. Journal of Immunology 204 (1) , pp. 112-121. 10.4049/jimmunol.1900455

Appanna, Gautham D, Pembroke, Thomas P I

, Miners, Kelly L, Price, David A

, Gallimore, Awen M

and Godkin, Andrew J

2019. Rituximab depletion of intrahepatic B cells to control refractory hepatic autoimmune overlap syndrome. QJM: An International Journal of Medicine 112 (10) , pp. 793-795. 10.1093/qjmed/hcz161

Meckiff, Benjamin J., Ladell, Kristin

, Ryan, Gordon B., Leese, Alison M., James, Eddie A., Price, David A. and Long, Heather M. 2019. Primary EBV infection induces an acute wave of activated antigen-specific cytotoxic CD4+ T cells. Journal of Immunology 203 (3) , ji1900377. 10.4049/jimmunol.1900377

Wong, Emily B., Gold, Marielle C., Meermeier, Erin W., Xulu, Bongiwe Z., Khuzwayo, Sharon, Sullivan, Zuri A., Mahyari, Eisa, Rogers, Zoe, Kløverpris, Hénrik, Sharma, Prabhat K., Worley, Aneta H., Lalloo, Umesh, Baijnath, Prinita, Ambaram, Anish, Naidoo, Leon, Suleman, Moosa, Madansein, Rajhmun, McLaren, James E.

, Miners, Kelly L., Price, David A.

, Behar, Samuel M., Nielsen, Morten, Kasprowicz, Victoria O., Leslie, Alasdair, Bishai, William R., Ndung'u, Thumbi and Lewinsohn, David M. 2019. TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis. Communications Biology 2 (1) , -. 10.1038/s42003-019-0442-2

Mohammed, Rebar N., Wehenkel, Sophie C., Galkina, Elena V., Yates, Emma-Kate, Preece, Graham, Newman, Andrew, Watson, H. Angharad, Ohme, Julia, Bridgeman, John S., Durairaj, Ruban R. P., Moon, Owen R., Ladell, Kristin

, Miners, Kelly L., Dolton, Garry, Troeberg, Linda, Kashiwagi, Masahide, Murphy, Gillian, Nagase, Hideaki, Price, David A.

, Matthews, R. James, Knauper, Vera

and Ager, Ann

2019. ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells. Scientific Reports 9 , 5487. 10.1038/s41598-019-41811-z

Li, Na, van Unen, Vincent, Abdelaal, Tamim, Guo, Nannan, Kasatskaya, Sofya A., Ladell, Kristin

, Egorov, Evgeny S., Izraelson, Mark, Chuva de Sousa Lopes, Susana M., Höllt, Thomas, Britanova, Olga V, Eggermont, Jeroen, de Miranda, Noel F. C. C., Chudakov, Dmitriy M., Price, David A.

, Lelieveldt, Boudewijn P. F. and Koning, Frits 2019. Memory CD4+ T cells are generated in the human fetal intestine. Nature Immunology 20 , pp. 301-312. 10.1038/s41590-018-0294-9

Mayassi, Toufic, Ladell, Kristin

, Gudjonson, Herman, McLaren, James E.

, Shaw, Dustin G., Tran, Mai T., Rokicka, Jagoda J., Lawrence, Ian, Grenier, Jean-Christophe, van Unen, Vincent, Ciszewski, Cezary, Dimaano, Matthew, Sayegh, Hoda E., Kumar, Vinod, Wijmenga, Cisca, Green, Peter H.R., Gokhale, Ranjana, Jericho, Hilary, Semrad, Carol E., Guandalini, Stefano, Dinner, Aaron R., Kupfer, Sonia S., Reid, Hugh H., Barreiro, Luis B., Rossjohn, Jamie

and Jabri, Bana 2019. Chronic inflammation permanently reshapes tissue-resident immunity in celiac disease. Cell 176 (5) , 967-981.e19. 10.1016/j.cell.2018.12.039

McLaren, James

, Clement, Mathew

, Marsden, Morgan, Miners, Kelly L., Llewellyn-Lacey, Sian, Grant, Emma J., Rubina, Anzelika, Gimeno Brias, Silvia, Gostick, Emma, Stacey, Maria A., Orr, Selinda J., Stanton, Richard J.

and Humphreys, Ian R.

2019. IL-33 augments virus-specific memory T Cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccinea. Journal of Immunology 202 (3) , pp. 943-955. 10.4049/jimmunol.1701757

Shimauchi, Takatoshi, Caucheteux, Stephan, Finsterbusch, Katja, Turpin, Jocelyn, Blanchet, Fabien, Ladell, Kristin

, Triantafilou, Kathy

, Czubala, Magdalena

, Tatsuno, Kazuki, Easter, Tammy, Ahmed, Zahra, Bayliss, Rebecca

, Hakobyan, Svetlana, Price, David A.

, Tokura, Yoshiki and Piguet, Vincent 2019. Dendritic cells promote the spread of human T-cell leukemia virus type 1 via bidirectional interactions with CD4+ T cells. Journal of Investigative Dermatology 139 (1) , pp. 157-166. 10.1016/j.jid.2018.06.188

Boelen, Lies, Debebe, Bisrat, Silveira, Marcos, Salam, Arafa, Makinde, Julia, Roberts, Chrissy h., Wang, Eddie C. Y.

, Frater, John, Gilmour, Jill, Twigger, Katie, Ladell, Kristin

, Miners, Kelly L., Jayaraman, Jyothi, Traherne, James A., Price, David A.

, Qi, Ying, Martin, Maureen P., Macallan, Derek C., Thio, Chloe L., Astemborski, Jacquie, Kirk, Gregory, Donfield, Sharyne M., Buchbinder, Susan, Khakoo, Salim I., Goedert, James J., Trowsdale, John, Carrington, Mary, Kollnberger, Simon and Asquith, Becca 2018. Inhibitory killer cell immunoglobulin-like receptors strengthen CD8+ T cell-mediated control of HIV-1, HCV, and HTLV-1. Science Immunology 3 (29) , eaao2892. 10.1126/sciimmunol.aao2892

Powell, Wendy E.

, Hanna, Stephanie J., Hocter, Claire N., Robinson, Emma, Davies, Joanne, Dunseath, Gareth J., Luzio, Stephen, Farewell, Daniel

, Wen, Li, Dayan, Colin M.

and Wong, F. Susan

2018. Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes. Diabetologia 61 , pp. 1794-1803. 10.1007/s00125-018-4651-x

Pogorelyy, Mikhail V., Fedorova, Alla D., McLaren, James E.

, Bagaev, Dmitri V., Eliseev, Alexey V., Mikelov, Artem I., Koneva, Anna E., Zvyagin, Ivan V., Price, David A.

, Chudakov, Dmitry M. and Shugay, Mikhail 2018. Exploring the pre-immune landscape of antigen-specific T cells. Genome Medicine 10 , 68. 10.1186/s13073-018-0577-7

Costa del Amo, Pedro, Beneytez, Julio Lahoz, Boelen, Lies, Ahmed, Raya, Miners, Kelly L., Zhang, Yan, Roger, Laureline, Jones, Rhiannon E., Marraco, Silvia A. Fuertes, Speiser, Daniel E., Baird, Duncan M.

, Macallan, Derek and Asquith, Becca 2018. Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness. PLoS Biology 16 (6) , e2005523. 10.1371/journal.pbio.2005523

Wun, Kwok S., Reijneveld, Josephine F., Cheng, Tan-Yun, Ladell, Kristin

, Uldrich, Adam P., Le Nours, Jérôme, Miners, Kelly L., McLaren, James E.

, Grant, Emma J., Haigh, Oscar L., Watkins, Thomas S., Suliman, Sara, Iwany, Sarah, Jimenez, Judith, Calderon, Roger, Tamara, Kattya L., Leon, Segundo R., Murray, Megan B., Mayfield, Jacob A., Altman, John D., Purcell, Anthony W., Miles, John J., Godfrey, Dale I., Gras, Stephanie, Price, David A.

, Van Rhijn, Ildiko, Moody, D. Branch and Rossjohn, Jamie

2018. T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids. Nature Immunology 19 , pp. 397-406. 10.1038/s41590-018-0065-7

Miles, John J., Tan, Mai Ping, Dolton, Garry, Edwards, Emily S. J.

, Galloway, Sarah A. E., Laugel, Bruno, Clement, Mathew

, Makinde, Julia, Ladell, Kristin

, Matthews, Katherine K., Watkins, Thomas S., Tungatt, Katie, Wong, Yide, Lee, Han Siean, Clark, Richard J., Pentier, Johanne M., Attaf, Meriem, Lissina, Anya, Ager, Ann

, Gallimore, Awen

, Rizkallah, Pierre J.

, Gras, Stephanie, Rossjohn, Jamie

, Burrows, Scott R., Cole, David K.

2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation 128 (4) , pp. 1569-1580. 10.1172/JCI91512

McCully, Michelle L., Ladell, Kristin

, Andrews, Robert, Jones, Rhiannon E., Miners, Kelly L., Roger, Laureline, Baird, Duncan M.

, Cameron, Mark J., Jessop, Zita M., Whitaker, Iain S., Davies, Eleri L., Price, David A. and Moser, Bernhard

2018. CCR8 expression defines tissue-resident memory T cells in human skin. Journal of Immunology 200 (5) , pp. 1639-1650. 10.4049/jimmunol.1701377

James, Eddie A., Abreu, Joana R. F., McGinty, John W., Odegard, Jared M., Fillié, Yvonne E., Hocter, Claire N., Culina, Slobodan, Ladell, Kristin

, Alkanani, Aimon, Rihanek, Marynette, Fitzgerald-Miller, Lisa, Skowera, Ania, Speake, Cate, Gottlieb, Peter, Davidson, Howard W., Wong, F. Susan

, Roep, Bart and Mallone, Roberto 2018. Combinatorial detection of autoreactive CD8+ T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop. Diabetologia 61 (3) , pp. 658-670. 10.1007/s00125-017-4508-8

Culina, Slobodan, Lalanne, Ana Ines, Afonso, Georgia, Cerosaletti, Karen, Pinto, Sheena, Sebastiani, Guido, Kuranda, Klaudia, Nigi, Laura, Eugster, Anne, Østerbye, Thomas, Maugein, Alicia, McLaren, James

, Larger, Etienne, Beressi, Jean-Paul, Lissina, Anna, Appay, Victor, Davidson, Howard W., Buus, Søren, Price, David

, Kuhn, Matthias, Bonifacio, Ezio, Battaglia, Manuela, Caillat-Zucman, Sophie, Dotta, Francesco, Scharfmann, Raphael, Kyewski, Bruno, Mallone, Roberto and ImMaDiab Study Group 2018. Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors. Science Immunology 3 (20) , eaao4013. 10.1126/sciimmunol.aao4013

Shugay, M., Bagaev, D. V., Zvyagin, I. V., Vroomans, R. M., Crawford, J. C., Dolton, Garry M., Komech, Ekaterina A., Sycheva, Anastasiya L., Koneva, Anna E., Egorov, Evgeniy S., Eliseev, Alexey V., Van Dyk, E., Dash, P., Attaf, Meriem, Ruis, Cristina, Ladell, Kristin Ingrid

, Matthews, Katherine K., Clemens, Ella B., Douek, Daniel C., Luciani, Fabio, Van Baarle, D., Kedzierska, Katherine, Kesmir, Can, Thomas, Paul G., Price, David

and Chudakov, Dimitry M. 2018. VDJdb: a curated database of T-cell receptor sequences with known antigen specificity. Nucleic Acids Research 46 (D1) , D419-D427. 10.1093/nar/gkx760

Lissina, Anna, McLaren, James E.

, Ilander, Mette, Andersson, Emma I., Lewis, Catherine S., Clement, Mathew

, Herman, Andrew, Ladell, Kristin

, Llewellyn-Lacey, Sian, Miners, Kelly L., Gostick, Emma, Melenhorst, J. Joseph, Barrett, A. John, Price, David A.

, Mustjoki, Satu and Wooldridge, Linda 2018. Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions. Scientific Reports 8 (1) , 2534. 10.1038/s41598-017-18062-x

Van Braeckel-Budimir, Natalija, Gras, Stephanie, Ladell, Kristin

, Josephs, Tracy M., Pewe, Lecia, Urban, Stina L., Miners, Kelly L., Farenc, Carine, Price, David A.

and Harty, John T. 2017. A T cell receptor locus harbors a malaria-specific immune response gene. Immunity 47 (5) , 835-847.e4. 10.1016/j.immuni.2017.10.013

Culshaw, Abigail, Ladell, Kristin

, Gras, Stephanie, McLaren, James E.

, Miners, Kelly L., Farenc, Carine, van den Heuvel, Heleen, Gostick, Emma, Dejnirattisai, Wanwisa, Wangteeraprasert, Apirath, Duangchinda, Thaneeya, Chotiyarnwong, Pojchong, Limpitikul, Wannee, Vasanawathana, Sirijitt, Malasit, Prida, Dong, Tao, Rossjohn, Jamie

, Mongkolsapaya, Juthathip, Price, David A.

and Screaton, Gavin R. 2017. Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response. Nature Immunology 18 , pp. 1228-1237. 10.1038/ni.3850

Anguille, Sébastien, Van de Velde, Ann L., Smits, Evelien L., Van Tendeloo, Viggo F., Juliusson, Gunnar, Cools, Nathalie, Nijs, Griet, Stein, Barbara, Lion, Eva, Van Driessche, Ann, Vandenbosch, Irma, Verlinden, Anke, Gadisseur, Alain P., Schroyens, Wilfried A., Muylle, Ludo, Vermeulen, Katrien, Maes, Marie-Berthe, Deiteren, Kathleen, Malfait, Ronald, Gostick, Emma, Lammens, Martin, Couttenye, Marie M., Jorens, Philippe, Goossens, Herman, Price, David

, Oka, Yoshihiro, Fujiki, Fumihiro, Oji, Yusuke, Sugiyama, Haruo and Berneman, Zwi N. 2017. Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia. Blood 130 (15) , pp. 1713-1721. 10.1182/blood-2017-04-780155

Murrell, Isa, Bedford, Carmen, Ladell, Kristin

, Miners, Kelly L., Price, David A.

, Tomasec, Peter, Wilkinson, Gavin W. G.

and Stanton, Richard J.

2017. The pentameric complex drives immunologically covert cell -cell transmission of wild-type human cytomegalovirus. Proceedings of the National Academy of Sciences 114 (23) , pp. 6104-6109. 10.1073/pnas.1704809114

Davey, Martin S., Willcox, Carrie R., Joyce, Stephen P., Ladell, Kristin

, Kasatskaya, Sofya A., McLaren, James E.

, Hunter, Stuart, Salim, Mahboob, Mohammed, Fiyaz, Price, David A.

, Chudakov, Dmitriy M. and Willcox, Benjamin E. 2017. Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance. Nature Communications 8 , 14760. 10.1038/ncomms14760

Dockree, Tamsin, Holland, Christopher J., Clement, Mathew

, Van Den Berg, Hugo A., Gostick, Emma, Llewellyn-Lacey, Sian, Man, Stephen Tzekwung

, Bailey, Mick, Burrows, Scott, Price, David

and Wooldridge, Linda 2017. CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold. Immunology and Cell Biology 95 (1) , pp. 68-76. 10.1038/icb.2016.85

Ahmed, Raya, Roger, Laureline, Costa del Amo, Pedro, Miners, Kelly L., Jones, Rhiannon E., Boelen, Lies, Fali, Tinhinane, Elemans, Marjet, Zhang, Yan, Appay, Victor, Baird, Duncan M.

, Asquith, Becca, Price, David A.

, Macallan, Derek C. and Ladell, Kristin

2016. Human stem cell-like memory T cells are maintained in a state of dynamic flux. Cell Reports 17 (11) , pp. 2811-2818. 10.1016/j.celrep.2016.11.037

Watson, H. Angharad, Dolton, Garry Michael, Ohme, Julia, Ladell, Kristin Ingrid

, Vigar, Miriam, Wehenkel, Sophie, Hindley, James, Mohammed, Rebar, Miners, Kelly, Luckwell, Rhys A, Price, David

, Matthews, R James and Ager, Ann

2016. Purity of transferred CD8+ T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1. Immunology and Cell Biology 94 (8) 10.1038/icb.2016.45

Caucheteux, Stephan M., Mitchell, John P., Ivory, Matthew O.

, Hirosue, Sachiko, Hakobyan, Svetlana, Dolton, Garry, Ladell, Kristin

, Miners, Kelly, Price, David A.

, Kan-Mitchell, June, Sewell, Andrew K.

, Nestle, Frank, Moris, Arnaud, Karoo, Richard O., Birchall, James C.

, Swartz, Melody A., Hubbel, Jeffrey A., Blanchet, Fabien P. and Piguet, Vincent 2016. Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1. Journal of Investigative Dermatology 136 (6) , pp. 1172-1181. 10.1016/j.jid.2016.01.033

Pearson, James A.

, Thayer, Terri C., McLaren, James E.

, De Leenheer, Evy, Phillips, Amy, Davies, Joanne, Kakabadse, Dimitri, Miners, Kelly, Morgan, Peter

, Wen, Li, Price, David A.

and Wong, F. Susan

2016. Proinsulin expression shapes the TCR repertoire but fails to control the development of low-avidity insulin-reactive CD8+ T cells. Diabetes 65 (6) , pp. 1679-1689. 10.2337/db15-1498

Du, V. Y., Bansal, A., Carlson, J., Salazar-Gonzalez, J. F., Salazar, M. G., Ladell, Kristin Ingrid

, Gras, S., Josephs, T. M., Heath, S. L., Price, David

, Hunter, E. and Goepfert, P. A. 2016. HIV-1-specific CD8 T cells exhibit limited cross-reactivity during acute infection. The Journal of Immunology 196 (8) , pp. 3276-3286. 10.4049/jimmunol.1502411

Ridley, Anna, Hatano, Hiroko, Wong-Baeza, Isabel, Shaw, Jacqueline, Matthews, Katherine K., Al-Mossawi, Hussein, Ladell, Kristin Ingrid

, Bowness, Paul and Kollnberger, Simon 2016. Activation-induced killer cell immunoglobulin-like receptor 3DL2 binding to HLA-B27 licenses pathogenic T cell differentiation in spondyloarthritis. Arthritis and Rheumatology 68 (4) , pp. 901-914. 10.1002/art.39515

Holland, Christopher J., Dolton, Garry M., Scurr, Martin

, Schauenburg, Andrea J., Miners, Kelly, Madura, Florian, Sewell, Andrew K.

, Cole, David K.

and Godkin, Andrew J.

2015. Enhanced detection of antigen-specific CD4+ T cells using altered peptide flanking residue peptide-MHC class II multimers. Journal of Immunology 195 (12) , pp. 5827-5836. 10.4049/jimmunol.1402787

Ladell, Kristin

, Hazenberg, Mette D., Fitch, Mark, Emson, Claire, McEvoy-Hein Asgarian, Bridget K., Mold, Jeff E., Miller, Corey, Busch, Robert, Price, David A.

, Hellerstein, Mark K. and McCune, Joseph M. 2015. Continuous antigenic stimulation of DO11.10 TCR transgenic mice in the presence or absence of IL-1: possible implications for mechanisms of T cell depletion in HIV disease. Journal of Immunology 195 (9) , pp. 4096-4105. 10.4049/jimmunol.1500799

Colbeck, Emily, Hindley, James P., Smart, Kathryn, Jones, Emma, Bloom, Anja, Bridgeman, Hayley, McPherson, Rhoanne C., Turner, Darryl G., Ladell, Kristin Ingrid

, O'Connor, Richard A., Anderton, Stephen M., Godkin, Andrew James

2015. Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors. Oncotarget 6 (28) , pp. 24649-24659. 10.18632/oncotarget.5584

Neller, Michelle A., Ladell, Kristin Ingrid

, Matthews, Katherine K., Gostick, Emma, Pentier, Johanne, Dolton, Garry Michael, Schauenburg, Andrea J. A., Koning, Dan, Fontaine Costa, Ana Isabel C. A., Watkins, Thomas S., Venturi, Vanessa, Smith, Corey, Khanna, Rajiv, Miners, Kelly Louise, Clement, Mathew

, Wooldridge, Linda, Cole, David

, van Baarle, Debbie, Sewell, Andrew K.

, Burrows, Scott R., Price, David

and Miles, John James 2015. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology 93 , pp. 625-633. 10.1038/icb.2015.17

Petersen, J., van Bergen, J., Loh, K. L., Kooy-Winkelaar, Y., Beringer, D. X., Thompson, A., Bakker, S. F., Mulder, C. J. J., Ladell, Kristin

, Reid, H. H. and Koning, F. 2015. Determinants of gliadin-specific T cell selection in celiac disease. The Journal of Immunology 194 (12) , pp. 6112-6122. 10.4049/jimmunol.1500161

Kloverpris, H. N., McGregor, R., McLaren, James Edward

, Harndahl, M., Stryhn, A., Carlson, J. M., Koofhethile, C., Gerritsen, B., Ke mir, C., Chen, F., Riddell, L., Luzzi, G., Leslie, A., Walker, B. D., Ndung'u, T., Buus, S., Price, David

and Goulder, P. J. 2015. CD8+ TCR bias and immunodominance in HIV-1 infection. The Journal of Immunology 194 (11) , pp. 5329-5345. 10.4049/jimmunol.1400854

Roberto, Alessandra, Castagna, Luca, Zanon, Veronica, Bramanti, Stefania, Crocchiolo, Roberto, McLaren, James E.

, Gandolfi, Sara, Tentorio, Paolo, Sarina, Barbara, Timofeeva, Inna, Santoro, Armando, Carlo-Stella, Carmelo, Bruno, Benedetto, Carniti, Cristiana, Corradini, Paolo, Gostick, Emma, Ladell, Kristin

, Roederer, Mario, Mavilio, Domenico and Lugli, Enrico 2015. Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation. Blood 125 (18) , pp. 2855-2864. 10.1182/blood-2014-11-608406

Skowera, Ania, Ladell, Kristin Ingrid

, Dolton, Garry Michael, Matthews, Katherine K., Gostick, Emma, Kronenberg-Versteeg, Deborah, Eichmann, Martin, Knight, Robin R., Heck, Susanne, Powrie, Jake, Bingley, Polly J., Dayan, Colin Mark

, Miles, John J., Sewell, Andrew K.

and Peakman, Mark 2015. β-Cell-specific CD8 T Cell phenotype in Type 1 diabetes reflects chronic autoantigen exposure. Diabetes 64 (3) , pp. 916-925. 10.2337/db14-0332

Parkinson, Nicholas J., Roddis, Matthew, Ferneyhough, Ben, Zhang, Gang, Marsden, Adam J., Maslau, Siarhei, Sanchez-Pearson, Yasmin, Barthlott, Thomas, Humphreys, Isla, Ladell, Kristin Ingrid

, Ponting, Chris P., Hollander, Georg and Fischer, Michael D. 2015. Violation of the 12/23 rule of genomic V(D)J recombination is common in lymphocytes. Genome Research 25 (2) , pp. 226-234. 10.1101/gr.179770.114

Costa, Ana I., Koning, Dan, Ladell, Kristin

, Grady, Bart P. X., Schellens, Ingrid M. M., van Ham, Petra, Nijhuis, Monique, Borghans, José A. M., Kesmir, Can, Price, David

, van Baarle, Debbie and Silvestri, G. 2015. Complex T-cell receptor repertoire dynamics underlie the CD8+T-cell response to HIV-1. Journal of Virology 89 (1) , pp. 110-119. 10.1128/JVI.01765-14

Willis, G. R., Connolly, K.

, Ladell, K.

, Davies, T. S., Guschina, I. A., Ramji, D.

, Miners, K., Price, D. A.

, Clayton, A.

, James, P. E. and Rees, D. A.

2014. Young women with polycystic ovary syndrome have raised levels of circulating annexin V-positive platelet microparticles. Human Reproduction 29 (12) , pp. 2756-2763. 10.1093/humrep/deu281

Tan, Mai, Gerry, A. B., Brewer, J. E., Melchiori, L., Bridgeman, John S., Bennett, A. D., Pumphrey, N. J., Jakobsen, B. K., Price, D. A., Ladell, Kristin Ingrid

2014. T cell receptor binding affinity governs the functional profile of cancer-specific CD8+T cells. Clinical and Experimental Immunology 180 (2) , pp. 255-270. 10.1111/cei.12570

Pearson, James, Thayer, T. C., McLaren, James Edward

, Miners, Kelly Louise, Ladell, Kristin Ingrid

and Wong, Florence Susan

2014. Analysis of the repertoire of insulin-reactive CD8(+) T cells [Abstract]. Immunology 143 (S2) , p. 152. 10.1111/imm.12406

Connolly, Katherine D.

, Willis, Gareth R., Datta, Dev B.N., Ellins, Elizabeth A.

, Guschina, Irina A., Rees, D. Aled

and James, Philip E. 2014. Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia. Journal of Lipid Research 55 , pp. 2064-2072. 10.1194/jlr.M049726

Taylor, Graham S., Jia, Hui, Harrington, Kevin, Lee, Lip Wai, Turner, James, Ladell, Kristin

, Tanday, Manjit, Matthews, Jen, Roberts, Claudia, Edwards, Ceri, McGuigan, Lesley, Hartley, Andrew, Wilson, Steve, Hui, Edwin P., Chan, Anthony T.C., Rickinson, Alan B. and Steven, Neil M. 2014. A recombinant modified vaccinia Ankara vaccine encoding Epstein-Barr virus (EBV) target antigens: a phase I trial in UK patients with EBV-positive cancer. Clinical Cancer Research 20 (19) , pp. 5009-5022. 10.1158/1078-0432.CCR-14-1122-T

Bengsch, Bertram, Ladell, Kristin Ingrid

, Martin, Bianca, McLaren, James Edward

, Nitschke, Katja, Neumann-Haefelin, Christoph, Price, David

and Thimme, Robert 2014. Identification of a TSCM phenotype HCV-specific CD8+T cell response with superior functionality in chronic HCV infection [Abstract]. Hepatology 60 , 1071A-1072A.

Kløverpris, Henrik N., McGregor, Reuben, McLaren, James Edward

, Stryhn, Anette, Koofhethile, Catherine, Brener, Jacqui, Chen, Fabian, Riddell, Lynn, Graziano, Luzzi, Klenerman, Paul, Leslie, Alasdair, Buus, Søren, Price, David

and Goulder, Philip 2014. Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load. AIDS 28 (14) , pp. 2007-2021. 10.1097/QAD.0000000000000362

Gold, Marielle C., McLaren, James E.

, Reistetter, Jospeh A., Smyk-Pearson, Sue, Ladell, Kristin

, Swarbrick, Gwendolyn M., Yu, Yik Y. L., Hansen, Ted H., Lund, Ole, Nielsen, Morten, Gerritsen, Bram, Kesmir, Can, Miles, John J., Lewinsohn, Deborah A., Price, David A.

and Lewinsohn, David M. 2014. MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage. Journal of Experimental Medicine 211 (8) , pp. 1601-1610. 10.1084/jem.20140507

Dolton, Garry Michael, Lissina, A., Skowera, A., Ladell, Kristin Ingrid

, Tungatt, Katie, Jones, Emma, Kronenberg-Versteeg, D., Akpovwa, Hephzibah, Pentier, Johanne, Holland, C. J., Godkin, Andrew James

, Cole, David

, Neller, M. A., Miles, John James, Price, David

, Peakman, M. and Sewell, Andrew K.

2014. Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells. Clinical and Experimental Immunology 177 (1) , pp. 47-63. 10.1111/cei.12339

Ondondo, Beatrice, Jones, Emma, Hindley, James, Cutting, Scott, Smart, Kathryn, Bridgeman, Hayley, Matthews, Katherine K., Ladell, Kristin Ingrid

, Jackson, David G., Godkin, Andrew James

, Ager, Ann

2014. Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naïve CD4+ T cellsviablood vessels and lymphatics. International Journal of Cancer 134 (9) , pp. 2156-2167. 10.1002/ijc.28556

Melamed, Anat, Witkover, Aviva D., Laydon, Daniel J., Brown, Rachael, Ladell, Kristin

, Miners, Kelly, Rowan, Aileen G., Gormley, Niall, Price, David

, Taylor, Graham P., Murphy, Edward L. and Bangham, Charles R. M. 2014. Clonality of HTLV-2 in natural infection. PLoS Pathogens 10 (3) , e1004006. 10.1371/journal.ppat.1004006

Bridgeman, John S., Ladell, Kristin Ingrid

, Sheard, V. E., Miners, Kelly Louise, Hawkins, R. E., Price, David

and Gilham, D. E. 2014. CD3ζ-based chimeric antigen receptors mediate T cell activation viacis- andtrans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy. Clinical and Experimental Immunology 175 (2) , pp. 258-267. 10.1111/cei.12216

Lissina, Anna, Fastenackels, Solène, Inglesias, Maria C., Ladell, Kristin

, McLaren, James

, Briceño, Olivia, Gostick, Emma, Papagno, Laura, Autran, Brigitte, Sauce, Delphine, Price, David

, Saez-Cirion, Asier and Appay, Victor 2014. The link between CD8+ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate. AIDS 28 (4) , pp. 477-486. 10.1097/QAD.0000000000000175

Bernasconi, Michele, Ueda, Seigo, Krukowski, Patricia, Bornhauser, Beat C., Ladell, Kristin Ingrid

, Dorner, Marcus, Sigrist, Juerg A., Campidelli, Cristina, Aslandogmus, Roberta, Alessi, Davide, Berger, Christoph, Pileri, Stefano A., Speck, Roberto F. and Nadal, David 2013. Early gene expression changes by Epstein-Barr virus infection of B-cells indicate CDKs and survivin as therapeutic targets for post-transplant lymphoproliferative diseases. International Journal of Cancer 133 (10) , pp. 2341-2350. 10.1002/ijc.28239

Scurr, Martin John

, Besneux, Matthieu, Christian, Adam, Hockey, T., Smart, Kathryn, Bridgeman, Hayley, Hargest, Rachel

, Phillips, S., Davies, M., Price, David

, Gallimore, Awen Myfanwy

and Godkin, Andrew James

2013. Highly prevalent colorectal cancer-infiltrating LAP+ Foxp3- T cells exhibit more potent immunosuppressive activity than Foxp3+ regulatory T cells. Mucosal Immunology n/a 10.1038/mi.2013.62

van den Berg, Hugo A., Ladell, Kristin

, Miners, Kelly, Laugel, Bruno, Llewellyn-Lacey, Sian, Clement, Mathew

, Cole, David

, Gostick, Emma, Wooldridge, Linda, Sewell, Andrew K.

, Bridgeman, John S. and Price, David

2013. Cellular-level versus receptor-level response threshold hierarchies in T-cell activation. Frontiers in Immunology 4 , 250. 10.3389/fimmu.2013.00250

Ladell, Kristin Ingrid

, Hashimoto, Masao, Iglesias, Maria Candela, Wilmann, Pascal G., McLaren, James Edward

, Gras, Stéphanie, Chikata, Takayuki, Kuse, Nozomi, Fastenackels, Solène, Gostick, Emma, Bridgeman, John S., Venturi, Vanessa, Arkoub, Zaïna Aït, Agut, Henri, van Bockel, David J., Almeida, Jorge R., Douek, Daniel C., Meyer, Laurence, Venet, Alain, Takiguchi, Masafumi, Rossjohn, Jamie

and Appay, Victor 2013. A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells. Immunity 38 (3) , pp. 425-436. 10.1016/j.immuni.2012.11.021

Koning, D., Costa, A. I., Hoof, I., Miles, John James, Nanlohy, N. M., Ladell, Kristin Ingrid

, Matthews, Katherine K., Venturi, V., Schellens, I. M. M., Borghans, J. A. M., Kesmir, C., Price, David

and van Baarle, D. 2013. CD8+ TCR repertoire formation is guided primarily by the peptide component of the antigenic complex. The Journal of Immunology 190 (3) , pp. 931-939. 10.4049/jimmunol.1202466

Chattopadhyay, P., Chelimo, K., Embury, P., Mulama, D., Sumba, P., Gostick, Emma, Ladell, Kristin Ingrid

, Brodie, T., Vulule, J., Roederer, M., Moormann, A. and Price, David

2013. Holoendemic malaria exposure is associated with altered epstein-barr virus-specific CD8+ T-cell differentiation. Journal of Virology 87 (3) , pp. 1779-1788. 10.1128/JVI.02158-12

Ladell, Kristin Ingrid

2013. Antigen-specific T cell turnover and expansion in vivo during chronic immune stimulation. PhD Thesis, Cardiff University.
Item availability restricted.

Humphreys, Ian R.

, Clement, Mathew

, Marsden, Morgan, Ladell, Kristin Ingrid

, Smart, Kathryn, Hindley, James Philip, Bridgeman, Hayley, van den Berg, Hugo A., Price, David

, Ager, Ann

, Wooldridge, Linda, Godkin, Andrew James

2012. Avidity of influenza-specific memory CD8+T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology 42 (12) , pp. 3235-3242. 10.1002/eji.201242575

McCully, Michelle L., Ladell, Kristin Ingrid

, Hakobyan, Svetlana, Mansel, Robert Edward

and Moser, Bernhard

2012. Epidermis instructs skin homing receptor expression in human T cells. Blood 120 (23) , pp. 4591-4598. 10.1182/blood-2012-05-433037

Hindley, James Phillip, Jones, Emma, Smart, Kathryn, Bridgeman, Hayley, Lauder, Sarah Nicol, Ondondo, Beatrice Omusiro, Cutting, Scott, Ladell, Kristin Ingrid

, Wynn, Katherine Kay, Withers, David, Price, David

, Ager, Ann

, Godkin, Andrew James

2012. T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T cell depletion. Cancer Research 72 (21) , pp. 5473-5482. 10.1158/0008-5472.CAN-12-1912

Ekeruche, Julia, Clement, Mathew

, Cole, David

, Edwards, Emily S. J.

, Miles, John James, Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry Michael, Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre

, Wooldridge, Linda and Sewell, Andrew K.

2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287 (44) , pp. 37269-37281. 10.1074/jbc.M112.386409

Ekeruche-Makinde, Julia, Clement, Mathew

, Cole, David K.

, Edwards, Emily S. J.

, Miles, John J., Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry M., Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre J.

, Wooldridge, Linda and Sewell, Andrew K.

2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287 (44) , pp. 37269-37281. 10.1074/jbc.M112.386409

Liddy, Nathaniel, Bossi, Giovanna, Adams, Katherine J., Lissina, Anna, Mahon, Tara M., Hassan, Namir J., Gavarret, Jessie, Bianchi, Frayne C., Pumphrey, Nicholas J., Ladell, Kristin Ingrid

, Gostick, Emma, Sewell, Andrew K.

, Lissin, Nikolai M., Harwood, Naomi E., Molloy, Peter E., Li, Yi, Cameron, Brian J., Sami, Malkit, Baston, Emma E., Todorov, Penio T., Paston, Samantha J., Dennis, Rebecca E., Harper, Jane V., Dunn, Steve M., Ashfield, Rebecca, Johnson, Andy, McGrath, Yvonne, Plesa, Gabriela, June, Carl H., Kalos, Michael, Price, David

, Vuidepot, Annelise, Williams, Daniel D., Sutton, Deborah H. and Jakobsen, Bent K 2012. Monoclonal TCR-redirected tumor cell killing. Nature Medicine 18 (6) , pp. 980-987. 10.1038/nm.2764

Cole, David

, Gallagher, Kathleen, Lemercier, Brigitte, Holland, Christopher J., Junaid, Sayed, Hindley, James Phillip, Wynn, Katherine Kay, Gostick, Emma, Sewell, Andrew K.

, Gallimore, Awen Myfanwy

, Gougeon, Marie-Lise and Godkin, Andrew James

2012. Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection. Nature Communications 3 , 665. 10.1038/ncomms1665

Doherty, T. Mark, Antrobus, Richard D., Lillie, Patrick J., Berthoud, Tamara K., Spencer, Alexandra J., McLaren, James E.

, Lambe, Teresa, Milicic, Anita, Price, David

, Hill, Adrian V. S. and Gilbert, Sarah C. 2012. A T Cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years. PLoS ONE 7 (10) , e48322. 10.1371/journal.pone.0048322

Clement, Mathew

, Ekeruche, Julia, Miles, John James, Edwards, Emily

, Dolton, Garry Michael, Williams, Tamsin, Schauenburg, Andrea J. A., Cole, David

, Lauder, Sarah Nicol, Gallimore, Awen Myfanwy

, Godkin, Andrew James

, Burrows, Scott R., Price, David

and Wooldridge, Linda 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187 (2) , pp. 654-663. 10.4049/jimmunol.1003941

Kreutzman, A., Ladell, Kristin Ingrid

, Koechel, C., Gostick, Emma, Ekblom, M., Stenke, L., Melo, T., Einsele, H., Porkka, K., Price, David

, Mustjoki, S. and Seggewiss, R. 2011. Expansion of highly differentiated CD8+ T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation. Leukemia 25 (10) , pp. 1587-1597. 10.1038/leu.2011.135

Hindley, James Philip, Ferreira, Cristina, Jones, Emma, Lauder, Sarah Nicol, Ladell, Kristin

, Wynn, Katherine, Betts, Gareth James, Singh, Yogesh, Price, David

, Godkin, Andrew James

, Dyson, Julian and Gallimore, Awen Myfanwy

2011. Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors. Cancer Research 71 (3) , pp. 736-746. 10.1158/0008-5472.CAN-10-1797

van Bockel, David J., Price, David

, Munier, Mee Ling, Venturi, Vanessa, Asher, Tedi E., Ladell, Kristin Ingrid

, Greenaway, Hui Yee, Zaunders, John, Douek, Daniel C., Cooper, David A., Davenport, Miles P. and Kelleher, Anthony D. 2010. Persistent survival of prevalent clonotypes within an immunodominant HIV gag-specific CD8+ T cell response. The Journal of Immunology 186 (1) , pp. 359-371. 10.4049/jimmunol.1001807

Jones, Morgan, Ladell, Kristin Ingrid

, Wynn, Katherine, Stacey, Maria A., Quigley, Maire F., Gostick, Emma, Price, David

and Humphreys, Ian R.

2010. IL-10 restricts memory T cell inflation during cytomegalovirus infection. The Journal of Immunology 185 (6) , pp. 3583-3592. 10.4049/jimmunol.1001535

Cole, David

, Edwards, Emily

, Wynn, Katherine, Clement, Mathew

, Miles, John James, Ladell, Kristin Ingrid

, Ekeruche, Julia, Gostick, Emma, Adams, Katherine J., Skowera, Ania, Peakman, Mark, Wooldridge, Linda, Price, David A.

2010. Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. The Journal of Immunology 185 (4) , pp. 2600-2610. 10.4049/jimmunol.1000629

Wooldridge, Linda, Clement, Mathew

, Lissina, Anna, Edwards, Emily

, Ekeruche, Julia, Hewitt, R. E., Laugel, Bruno Frederic, Gostick, Emma, Cole, David

, Debets, R., Berrevoets, C., Miles, John James, Burrows, S. R., Price, David A.

2010. MHC Class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. Journal of Immunology 184 (7) , pp. 3357-3366. 10.4049/jimmunol.0902398

Van Tendeloo, V. F., Van de Velde, A., Van Driessche, A., Cools, N., Anguille, S., Ladell, Kristin Ingrid

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